{"id":11949,"date":"2023-07-06T12:28:01","date_gmt":"2023-07-06T10:28:01","guid":{"rendered":"https:\/\/new.sano.science\/?post_type=people&p=11949"},"modified":"2026-02-20T11:36:46","modified_gmt":"2026-02-20T10:36:46","slug":"adam-sulek","status":"publish","type":"people","link":"https:\/\/sano.science\/people\/adam-sulek\/","title":{"rendered":"Adam Su\u0142ek"},"excerpt":{"rendered":"

Postdoctoral Researcher<\/p>\n","protected":false},"featured_media":18595,"template":"","people_teams":[19,114],"class_list":["post-11949","people","type-people","status-publish","has-post-thumbnail","hentry","people_teams-research","people_teams-structural-and-functional-genomics-group"],"yoast_head":"\nAdam Su\u0142ek - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/people\/adam-sulek\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adam Su\u0142ek\" \/>\n<meta property=\"og:description\" content=\"Postdoctoral Researcher\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/people\/adam-sulek\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-20T10:36:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sano.science\/wp-content\/uploads\/2023\/07\/Sano-Adam-Sulek.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/adam-sulek\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/people\\\/adam-sulek\\\/\",\"name\":\"Adam Su\u0142ek - 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His interdisciplinary research was conducted in collaboration with the Lukasiewicz Research Network – Krak\u00f3w Institute of Technology and the Faculty of Mathematics and Computer Science at the Jagiellonian University. Adam’s research interests include molecular processes in tumor proliferation, computer-aided drug design, and structural biology.<\/p>\n<p>Currently, he is working on a project that examines cell cycle dysregulation, specifically involving BRCA and CDK, which leads to uncontrolled cell proliferation. Another of his projects focuses on understanding protein thermostability and exploring the use of Protein Language Models in this field.<\/p>\n","email":"","social_media":false,"tabs":false,"quote":"","position_with_team":{"text_before_link":"Postdoctoral Researcher in","link_text":"Structural and Functional Genomics Group","text_after_link":"","link":"https:\/\/sano.science\/research-teams\/structural-and-functional-genomics\/"},"publications":[{"ID":20689,"post_author":"8","post_date":"2025-01-10 12:56:32","post_date_gmt":"2025-01-10 11:56:32","post_content":"<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-XgRZTp\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-sCnvNo\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-barbara-pucelik-agata-barzowska-adam-sulek-mateusz-werlos-janusz-m-dabrowski\">Barbara Pucelik, Agata Barzowska, Adam Su\u0142ek, Mateusz Wer\u0142os, Janusz M. D\u0105browski<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-XgRZTp\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-O8zz1E\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Antibiotic resistance has become a critical global health issue, recognized within the One Health framework. Photodynamic inactivation of microorganisms (PDI) offers a promising non-invasive alternative, effective across a broad spectrum with minimal resistance risk. This study presents the synthesis, photophysical properties, and antimicrobial effects of a palladium(II)-porphyrin derivative (PdF2POH) along with its zinc(II) and free-base variants (ZnF2POH, F2POH). PdF2POH demonstrated exceptional reactive oxygen species (ROS) generation, including singlet oxygen (\u03a6\u25b3 = 0.93) and oxygen-centered radicals, confirmed through luminescence and fluorescent probe assays. All compounds exhibited strong activity against Gram-positive bacteria, with PdF2POH achieving a 6-log reduction in <em>S. aureus<\/em> viability, including biofilm disruption. PdF2POH-mediated PDI showed selectivity for bacterial over mammalian cells, particularly under lower blue light doses (up to 5 J\/cm\u00b2). Its superior efficacy over ZnF2POH and F2POH is attributed to higher ROS production through both photochemical pathways. Furthermore, PdF2POH effectively eliminated bacteria in <em>S. aureus<\/em>-infected human keratinocytes while preserving cell viability. These findings highlight Pd(II)-porphyrin as a promising photosensitizer for combating bacterial infections, supporting further exploration in advanced infection models.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-XgRZTp\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-YQZSzK\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: doi.org\/10.1007\/s43630-024-00538-1<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-8JFSti\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>:\u00a0Antibiotic resistancePhotodynamic inactivation (PDI)PhotosensitizerPalladium(II)-porphyrin (PdF2POH)Reactive oxygen species (ROS)Singlet oxygenGram-positive bacteria<em>Staphylococcus aureus<\/em>Biofilm disruptionZinc(II)-porphyrin (ZnF2POH)Human keratinocytesBacterial infection therapyOne Health framework<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-XgRZTp\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_67810ab796e63\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/link.springer.com\/article\/10.1007\/s43630-024-00538-1\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Refining antimicrobial photodynamic therapy: effect of charge distribution and central metal ion in fluorinated porphyrins on effective control of planktonic and biofilm bacterial forms","post_excerpt":"Journal paper in: link.springer.com, 2024","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"refining-antimicrobial-photodynamic-therapy-effect-of-charge-distribution-and-central-metal-ion-in-fluorinated-porphyrins-on-effective-control-of-planktonic-and-biofilm-bacterial-forms","to_ping":"","pinged":"","post_modified":"2025-01-10 13:04:42","post_modified_gmt":"2025-01-10 12:04:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&p=20689","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"}]},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/11949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/people"}],"version-history":[{"count":17,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/11949\/revisions"}],"predecessor-version":[{"id":29241,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/11949\/revisions\/29241"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media\/18595"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=11949"}],"wp:term":[{"taxonomy":"people_teams","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people_teams?post=11949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}