{"id":11964,"date":"2023-07-06T12:40:52","date_gmt":"2023-07-06T10:40:52","guid":{"rendered":"https:\/\/new.sano.science\/?post_type=people&p=11964"},"modified":"2025-02-17T17:52:47","modified_gmt":"2025-02-17T16:52:47","slug":"jakub-jonczyk","status":"publish","type":"people","link":"https:\/\/sano.science\/people\/jakub-jonczyk\/","title":{"rendered":"Jakub Jo\u0144czyk"},"excerpt":{"rendered":"

PostDoc in Clinical Data Science<\/p>\n","protected":false},"featured_media":11965,"template":"","people_teams":[24],"class_list":["post-11964","people","type-people","status-publish","has-post-thumbnail","hentry","people_teams-alumni"],"yoast_head":"\nJakub Jo\u0144czyk - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/people\/jakub-jonczyk\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jakub Jo\u0144czyk\" \/>\n<meta property=\"og:description\" content=\"PostDoc in Clinical Data Science\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/people\/jakub-jonczyk\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-17T16:52:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sano.science\/wp-content\/uploads\/2023\/07\/jakub_jonczyk.png\" \/>\n\t<meta property=\"og:image:width\" content=\"350\" \/>\n\t<meta property=\"og:image:height\" content=\"350\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/jakub-jonczyk\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/people\\\/jakub-jonczyk\\\/\",\"name\":\"Jakub Jo\u0144czyk - 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His doctoral research concerns the application of molecular modeling in drug design, specifically in designing multitarget ligands for future Alzheimer\u2019s treatment. After that Jakub spent one year as a assistant professor with the Medicinal Chemistry Department at Jagiellonian University teaching and expanding his research with machine learning techniques. At Sano, he joined the Clinical Data Science Team for his PostDoc training. He aims to build his computational knowledge to advance his career as a medical chemistry. He is excited is collaborate with a vibrant interdiscplanary team of computer scientists, biologists, pharmacologist to provide a better response to the needs of patients and medical professionals around the world.<\/p>\n","email":"","social_media":[{"icon":{"ID":11994,"id":11994,"title":"linkedin","filename":"linkedin.svg","filesize":914,"url":"https:\/\/sano.science\/wp-content\/uploads\/2023\/05\/linkedin.svg","link":"https:\/\/sano.science\/people\/maciej-malawski\/linkedin-2\/","alt":"","author":"5","description":"","caption":"","name":"linkedin-2","status":"inherit","uploaded_to":531,"date":"2023-07-06 11:24:13","modified":"2023-07-06 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Lubica Muckova, Dr. Nela V\u00e1nova, Pola Dryja, Prof.\u2005Dr. Kinga Sa\u0142at, Dr. Georg H\u00f6fner, Prof.\u2005Dr. Klaus Wanner, Dr. Anna Wi\u0119ckowska, Prof.\u2005Dr. Barbara Malawska<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"30px\",\"epAnimationGeneratedClass\":\"edplus_anim-V2l7ci\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-7dFj5s\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Progressive cognitive decline characterizing Alzheimer's disease (AD) includes memory impairments and various behavioral and psychological symptoms of dementia (BPSD). Treatments traditionally target the predominantly affected cholinergic neurons to boost neurotransmission. However, dysfunctions in additional neurotransmitters such as \u03b3-aminobutyric acid (GABA) also significantly influence AD\u2019s clinical manifestations. This research introduces compound 6, developed through a blend of crystallography and computational analytics, serving as a dual regulator of GABAergic and cholinergic transmission. It effectively inhibits BuChE (IC50=0.21\u2005\u03bcM) and GABA transporters 1 (IC50=10.96\u2005\u03bcM) and 3 (IC50=7.76\u2005\u03bcM), with a robust profile suitable for drug development. Compound 6's efficacy in improving memory retention and mitigating symptoms of anxiety and depression was confirmed through in vivo tests, showing it to be safe and orally bioavailable. Offering a novel, multi-targeted therapeutic strategy, compound 6 holds potential for managing cognitive deficits and BPSD in Alzheimer\u2019s disease.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"30px\",\"epAnimationGeneratedClass\":\"edplus_anim-V2l7ci\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-p5dL3M\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: 10.1002\/anie.202420510<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"30px\",\"epAnimationGeneratedClass\":\"edplus_anim-V2l7ci\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_67b35e96c50b1\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202420510\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease","post_excerpt":"In: Angewandte Chemie International Edition, 2024","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"multifunctional-fluorene-based-modulator-of-cholinergic-and-gabaergic-neurotransmission-as-a-novel-drug-candidate-for-palliative-treatment-of-alzheimers-disease","to_ping":"","pinged":"","post_modified":"2025-02-17 17:51:45","post_modified_gmt":"2025-02-17 16:51:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&p=21508","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"}]},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/11964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/people"}],"version-history":[{"count":3,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/11964\/revisions"}],"predecessor-version":[{"id":21523,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/11964\/revisions\/21523"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media\/11965"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=11964"}],"wp:term":[{"taxonomy":"people_teams","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people_teams?post=11964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}