{"id":12218,"date":"2023-07-07T13:44:07","date_gmt":"2023-07-07T11:44:07","guid":{"rendered":"https:\/\/new.sano.science\/?post_type=people&p=12218"},"modified":"2025-01-13T09:27:59","modified_gmt":"2025-01-13T08:27:59","slug":"andrew-narracott","status":"publish","type":"people","link":"https:\/\/sano.science\/people\/andrew-narracott\/","title":{"rendered":"Andrew Narracott"},"excerpt":{"rendered":"

Senior Lecturer in Cardiovascular Mechanics in the Department of Infection, Immunity and Cardiovascular Disease and Director of Operations for Insigneo at the University of Sheffield<\/p>\n","protected":false},"featured_media":13453,"template":"","people_teams":[44,43,23],"class_list":["post-12218","people","type-people","status-publish","has-post-thumbnail","hentry","people_teams-university-of-sheffield","people_teams-foundation-council","people_teams-partners"],"yoast_head":"\nAndrew Narracott - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/people\/andrew-narracott\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Andrew Narracott\" \/>\n<meta property=\"og:description\" content=\"Senior Lecturer in Cardiovascular Mechanics in the Department of Infection, Immunity and Cardiovascular Disease and Director of Operations for Insigneo at the University of Sheffield\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/people\/andrew-narracott\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-13T08:27:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sano.science\/wp-content\/uploads\/2023\/07\/andrew_narracott-2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"350\" \/>\n\t<meta property=\"og:image:height\" content=\"350\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/andrew-narracott\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/people\\\/andrew-narracott\\\/\",\"name\":\"Andrew Narracott - 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He is Sheffield\u2019s Principal Investigator for the Sano project, coordinating the contribution of Insigneo in facilitating Sano to develop and translate innovative solutions for computational medicine. Andrew\u2019s work is strongly focused on identifying and progressing the fundamental and readily-translatable elements of computational physiology, to advance clinical practice.<\/p>\n","email":"","social_media":false,"tabs":false,"quote":"","position_with_team":{"text_before_link":"","link_text":"","text_after_link":"","link":""},"publications":[{"ID":20841,"post_author":"8","post_date":"2025-01-13 09:25:52","post_date_gmt":"2025-01-13 08:25:52","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-RWEf8c\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-karolina-tlalka-nbsp-harry-saxton-ian-halliday-xu-xu-andrew-narracott-daniel-taylor-maciej-malawski\">Karolina Tla\u0142ka , Harry Saxton, Ian Halliday, Xu Xu, Andrew Narracott, Daniel Taylor, Maciej Malawski<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-EFq7Vk\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-2RHCud\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">The baroreflex plays a crucial role in regulating the human cardiovascular system. This study employs a closed-loop in silico model of baroreflex control, integrated with pulsatile mechanical models featuring (i) a single heart chamber with 36 parameters and (ii) four chambers with 51 parameters. For the first time, a global sensitivity analysis is conducted on these closed-loop systems, accounting for both cardiovascular and baroreflex parameters. The results are compared with non-regulated versions of the models. Findings indicate that regulated parameters have a lower impact compared to non-regulated counterparts, and in a physiological resting state, outputs such as pressure, heart rate, and cardiac output are primarily influenced by parasympathetic arc parameters. This research enhances the understanding of regulation effects and parameter influence on clinical metrics, contributing to the development of personalized healthcare models.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-EFq7Vk\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-K67hWw\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: 10.1371\/journal.pcbi.1012377<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-kzZIS0\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: baroreflex, sensitivity analysis, cardiovascular system<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-EFq7Vk\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_6784cd51f8522\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1012377\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex","post_excerpt":"Journal paper: journals.plos.org, 2024","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sensitivity-analysis-of-closed-loop-one-chamber-and-four-chamber-models-with-baroreflex","to_ping":"","pinged":"","post_modified":"2025-01-13 12:27:51","post_modified_gmt":"2025-01-13 11:27:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&p=20841","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"}]},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/people"}],"version-history":[{"count":3,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12218\/revisions"}],"predecessor-version":[{"id":20848,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12218\/revisions\/20848"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media\/13453"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=12218"}],"wp:term":[{"taxonomy":"people_teams","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people_teams?post=12218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}