{"id":12281,"date":"2023-07-07T15:52:38","date_gmt":"2023-07-07T13:52:38","guid":{"rendered":"https:\/\/new.sano.science\/?post_type=people&#038;p=12281"},"modified":"2026-01-31T20:30:20","modified_gmt":"2026-01-31T19:30:20","slug":"sabina-licholai","status":"publish","type":"people","link":"https:\/\/sano.science\/people\/sabina-licholai\/","title":{"rendered":"Sabina Licho\u0142ai"},"excerpt":{"rendered":"<p>Medical Doctor, Graduated from the Jagiellonian University<\/p>\n","protected":false},"featured_media":13469,"template":"","people_teams":[24],"class_list":["post-12281","people","type-people","status-publish","has-post-thumbnail","hentry","people_teams-alumni"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sabina Licho\u0142ai - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/people\/sabina-licholai\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sabina Licho\u0142ai\" \/>\n<meta property=\"og:description\" content=\"Medical Doctor, Graduated from the Jagiellonian University\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/people\/sabina-licholai\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-31T19:30:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sano.science\/wp-content\/uploads\/2023\/07\/Sabina_Licholai-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"350\" \/>\n\t<meta property=\"og:image:height\" content=\"350\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/sabina-licholai\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/people\\\/sabina-licholai\\\/\",\"name\":\"Sabina Licho\u0142ai - 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She implemented high-throughput biological measurements as well as bioinformatics and computing techniques in order to obtain molecular profiles characteristic for particular human conditions. She is a genetics consultant for Sano. She was involved in various Polish and international scientific projects.<\/p>\n","email":"","social_media":false,"tabs":false,"quote":"","position_with_team":{"text_before_link":"","link_text":"","text_after_link":"","link":""},"publications":[{"ID":28615,"post_author":"8","post_date":"2026-01-31 20:24:45","post_date_gmt":"2026-01-31 19:24:45","post_content":"<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-QsRcd7\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Piotr Kica, Sabina Licho\u0142ai, Micha\u0142 Orzechowski, Maciej Malawski<br><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"20px\",\"epAnimationGeneratedClass\":\"edplus_anim-4mOOA5\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_697e56e4fb8d8\",\"name\":\"acf\/button\",\"data\":{\"title\":\"Read\/Download\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/arxiv.org\/pdf\/2506.12611\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Accelerating Cloud-Based Transcriptomics: Performance Analysis and Optimization of the STAR Aligner Workflow","post_excerpt":"Conference manuscript: 25th International Conference on Computational Science, 2025","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"accelerating-cloud-based-transcriptomics-performance-analysis-and-optimization-of-the-star-aligner-workflow","to_ping":"","pinged":"","post_modified":"2026-01-31 20:24:54","post_modified_gmt":"2026-01-31 19:24:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=28615","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28622,"post_author":"8","post_date":"2026-01-31 20:27:39","post_date_gmt":"2026-01-31 19:27:39","post_content":"<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-2Pi2d5\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">J. Meizner, P. Kica, S. Licho\u0142ai, M. Malawski<br><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"20px\",\"epAnimationGeneratedClass\":\"edplus_anim-1zPQcu\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_697e57c573194\",\"name\":\"acf\/button\",\"data\":{\"title\":\"Read\/Download\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/events.plgrid.pl\/event\/70\/attachments\/143\/364\/PROCEEDINGS%202025_na%20www%20bez%20notatek.pdf\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-kY6bTP\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><\/p>\n<!-- \/wp:paragraph -->","post_title":"Analysis of Index Access Pattern in STAR RNA-seq Aligner","post_excerpt":"Conference abstract: Seventeenth ACC Cyfronet AGH HPC Users\u2019 Conference (KUKDM 2025), 2025","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"analysis-of-index-access-pattern-in-star-rna-seq-aligner","to_ping":"","pinged":"","post_modified":"2026-02-06 11:42:54","post_modified_gmt":"2026-02-06 10:42:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=28622","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12961,"post_author":"5","post_date":"2023-08-02 15:42:47","post_date_gmt":"2023-08-02 13:42:47","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-2smthB\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\">Licho\u0142ai, S.; Studzi\u0144ska, D.; Plutecka, H.; Guba\u0142a, T.; Sanak, M.<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-7g5gXo\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-fiarPb\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Non-coding RNAs constitute a heterogeneous group of molecules that lack the ability to encode proteins but retain the potential ability to influence cellular processes through a regulatory mechanism. Of these proteins, microRNAs, long non-coding RNAs, and more recently, circular RNAs have been the most extensively described. However, it is not entirely clear how these molecules interact with each other. For circular RNAs, the basics of their biogenesis and properties are also lacking. Therefore, in this study we performed a comprehensive analysis of circular RNAs in relation to endothelial cells. We identified the pool of circular RNAs present in the endothelium and showed their spectrum and expression across the genome. Using different computational strategies, we proposed approaches to search for potentially functional molecules. In addition, using data from an in vitro model that mimics conditions in the endothelium of an aortic aneurysm, we demonstrated altered expression levels of circRNAs mediated by microRNAs.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-7g5gXo\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_64ca5de90ea84\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/10025\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_blank\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Comprehensive Analysis of Circular RNAs in Endothelial Cells","post_excerpt":"In: International Journal of Molecular Sciences, 2023","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"comprehensive-analysis-of-circular-rnas-in-endothelial-cells","to_ping":"","pinged":"","post_modified":"2024-01-18 10:06:54","post_modified_gmt":"2024-01-18 09:06:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=12961","menu_order":20,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14870,"post_author":"5","post_date":"2024-01-12 16:50:17","post_date_gmt":"2024-01-12 15:50:17","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-73aQsf\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\">Paulina Szadkowska, Adria-Jaume Roura, Bartosz Wojtas, Kamil Wojnicki, Sabina Licholai, Tomasz Waller, Tomasz Gubala, Kacper Zukowski, Michal Karpeta, Kinga Wilkus, Wojciech Kaspera, Sergiusz Nawrocki, Bozena Kaminska<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-qTKwHi\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-ggVswq\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Malignant gliomas are the most frequent primary brain tumors in adults. They are genetically heterogenous and invariably recur due to incomplete surgery and therapy resistance. Circulating tumor DNA (ctDNA) is a component of circulating cell-free DNA (ccfDNA) and represents genetic material that originates from the primary tumor or metastasis. Brain tumors are frequently located in the eloquent brain regions, which makes biopsy difficult or impossible due to severe postoperative complications. The analysis of ccfDNA from a patient\u2019s blood presents a plausible and noninvasive alternative. In this study, freshly frozen tumors and corresponding blood samples were collected from 84 brain tumor patients and analyzed by targeted next-generation sequencing (NGS). The cohort included 80 glioma patients, 2 metastatic cancer patients, and 2 primary CNS lymphoma (PCNSL) patients. We compared the pattern of genetic alterations in the tumor DNA (tDNA) with that of ccfDNA. The implemented technical improvements in quality control and library preparation allowed for the detection of ctDNA in 8 out of 84 patients, including 5 out of 80 glioma patients. In 32 out of 84 patients, we found potentially pathogenic genetic alterations in ccfDNA that were not detectable in tDNA. While sequencing ccfDNA from plasma has a low efficacy as a diagnostic tool for glioma patients, we concluded that further improvements in sample processing and library preparation can make liquid biopsy a valuable diagnostic tool for glioma patients.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-qTKwHi\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_65a12794756ad\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/www.mdpi.com\/2072-6694\/14\/16\/3902\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_blank\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Improvements in Quality Control and Library Preparation for Targeted Sequencing Allowed Detection of Potentially Pathogenic Alterations in Circulating Cell-Free DNA Derived from Plasma of Brain Tumor Patients","post_excerpt":"In: Cancers, 2022.","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"improvements-in-quality-control-and-library-preparation-for-targeted-sequencing-allowed-detection-of-potentially-pathogenic-alterations-in-circulating-cell-free-dna-derived-from-plasma-of-brain-tumor","to_ping":"","pinged":"","post_modified":"2024-01-16 12:55:26","post_modified_gmt":"2024-01-16 11:55:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=14870","menu_order":74,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14841,"post_author":"5","post_date":"2024-01-10 20:28:19","post_date_gmt":"2024-01-10 19:28:19","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-N27mw0\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\">K. W\u00f3jcik, A. \u0106miel,<strong> T. Sat\u0142awa, S. Licho\u0142ai, <\/strong>K. Wawrzycka-Adamczyk, G. Biedro\u0144, A. Masiak, Z. Zdrojewski, H. Storoniak, B. Bu\u0142\u0142o-Piontecka, A. D\u0119bska-\u015alizie\u0144, R. Jeleniewicz, M. Majdan, K. Jakuszko, H. Augustyniak-Bartosik, M. Krajewska, I. Brzosko, M. Brzosko, J. Kur-Zalewska, W. T\u0142ustochowicz, M. Madej, A. Hawrot-Kawecka, E. Kucharz, P. G\u0142uszko, M. Wis\u0142owska, J. Mi\u0142kowska-Dymanowska, A. Lewandowska-Polak, J. Makowska, J. Zalewska,<strong> T. Guba\u0142a, M. Malawski, <\/strong>J. Musia\u0142<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-eJavZq\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_659eefbce7052\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/ard.bmj.com\/content\/81\/Suppl_1\/367.1\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_blank\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Personalized risk evaluation for outcome prediction in anca associated vasculitis (aav) using latent class analysis and machine learning","post_excerpt":"In: Annals of the Rheumatic Diseases The EULAR Journal \u2013 European Congress of Rheumatology 2022.","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"personalized-risk-evaluation-for-outcome-prediction-in-anca-associated-vasculitis-aav-using-latent-class-analysis-and-machine-learning","to_ping":"","pinged":"","post_modified":"2024-01-26 14:19:34","post_modified_gmt":"2024-01-26 13:19:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=14841","menu_order":53,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14829,"post_author":"5","post_date":"2024-01-10 20:00:40","post_date_gmt":"2024-01-10 19:00:40","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-uqaeKt\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\">K. W\u00f3jcik, A. \u0106miel, <strong>T. Sat\u0142awa, S. Licho\u0142ai, <\/strong>K. Wawrzycka-Adamczyk, G. Biedro\u0144, A. Masiak, Z. Zdrojewski, H. Storoniak, B. Bu\u0142\u0142o-Piontecka, A. D\u0119bska-\u015alizie\u0144, R. Jeleniewicz, M. Majdan, K. Jakuszko, H. Augustyniak-Bartosik, M. Krajewska, I. Brzosko, M. Brzosko, J. Kur-Zalewska, W. T\u0142ustochowicz, M. Madej, A. Hawrot-Kawecka, E. Kucharz, P. G\u0142uszko, M. Wis\u0142owska, J. Mi\u0142kowska-Dymanowska, A. Lewandowska-Polak, J. Makowska, J. Zalewska,<strong> T. Guba\u0142a, M. Malawski<\/strong>, J. Musia\u0142<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-fkALYP\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_659ee97b86d3c\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/zenodo.org\/records\/6454077\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_blank\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Subgrouping and personalized risk evaluation for outcome prediction in ANCA associated vasculitis (AAV)","post_excerpt":"In: Autoimmunity, Autoinflammation and Immunodeficiency in Vasculitis Abstracts of the 20th International Vasculitis & ANCA Workshop, Dublin, Ireland 3-6 April 2022, 2022.","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"subgrouping-and-personalized-risk-evaluation-for-outcome-prediction-in-anca-associated-vasculitis-aav","to_ping":"","pinged":"","post_modified":"2024-01-10 20:03:07","post_modified_gmt":"2024-01-10 19:03:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=14829","menu_order":54,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14655,"post_author":"5","post_date":"2024-01-05 13:30:35","post_date_gmt":"2024-01-05 12:30:35","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-PcobWA\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\"><strong>Sabina Licho\u0142ai,<\/strong> Dorota Studzi\u0144ska, Hanna Plutecka, <strong>Tomasz Guba\u0142a,<\/strong> Wojciech Szczeklik and Marek Sanak<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-0d6JGP\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:heading {\"level\":4,\"epAnimationGeneratedClass\":\"edplus_anim-ludDo0\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h4 class=\"wp-block-heading eplus-wrapper\" id=\"html-abstract-title\">Abstract<\/h4>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-WNbMwk\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Abdominal aortic aneurysms (AAA) are a complex disease with an unclear pathomechanism. A positive family history is emphasized as a significant risk factor, and a nonspecific model of inheritance suggests participation of epigenetic regulation in the pathogenesis of this disease. Past studies have implicated microRNAs in the development of AAA; therefore in this project, we measured miR-191 levels in AAA patients and compared them with a control group. We found that miR-191 levels were significantly elevated in aneurysmal patients, although this did not correlate with the available clinical data. We then developed an in vitro model where, using cells with an endothelial phenotype, we determined the effect of miR-191 on the transcriptome using RNA sequencing. Subsequent pathway analysis established that some of the perturbations mediated by miR-191 can be explained by several processes which have long been observed and described in literature as accompanying the development of abdominal aortic aneurysms.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"10px\",\"epAnimationGeneratedClass\":\"edplus_anim-fwSDiE\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-iNxTDT\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>:&nbsp;abdominal aortic aneurysms;&nbsp;microRNA;&nbsp;endothelial dysfunction<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-sG6h9g\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_6597f5f41f085\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/www.mdpi.com\/2218-273X\/11\/11\/1611\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_blank\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling","post_excerpt":"In: Biomolecules, 2021.","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mir-191-as-a-key-molecule-in-aneurysmal-aortic-remodeling","to_ping":"","pinged":"","post_modified":"2024-01-05 13:49:57","post_modified_gmt":"2024-01-05 12:49:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=14655","menu_order":90,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14344,"post_author":"5","post_date":"2023-11-20 12:26:08","post_date_gmt":"2023-11-20 11:26:08","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-zZU7Yz\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\">Jan Przybyszewski, Maciej Malawski, Sabina Licho\u0142ai<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-PANA9P\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-r4kzb3\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">MicroRNAs (miRNAs) are short, non-coding RNA molecules that regulate gene expression by binding to specific mRNAs, inhibiting their translation. They play a critical role in regulating various biological processes and are implicated in many diseases, including cardiovascular, oncological, gastrointestinal diseases, and viral infections. Computational methods that can identify potential miRNA\u2013mRNA interactions from raw data use one-dimensional miRNA\u2013mRNA duplex representations and simple sequence encoding techniques, which may limit their performance.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-cIuExl\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:group {\"layout\":{\"type\":\"constrained\"},\"epAnimationGeneratedClass\":\"edplus_anim-h2err4\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div class=\"wp-block-group eplus-wrapper\"><!-- wp:acf\/button {\"id\":\"block_655b43db0b318\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/link.springer.com\/article\/10.1186\/s12859-023-05564-x?utm_source=rct_congratemailt\\u0026utm_medium=email\\u0026utm_campaign=oa_20231117\\u0026utm_content=10.1186\/s12859-023-05564-x\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_blank\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/--><\/div>\n<!-- \/wp:group -->","post_title":"GraphTar: applying word2vec and graph neural networks to miRNA target prediction","post_excerpt":"In: BMCBioinformatics, 2023.","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"graphtar-applying-word2vec-and-graph-neural-networks-to-mirna-target-prediction","to_ping":"","pinged":"","post_modified":"2024-01-18 10:27:28","post_modified_gmt":"2024-01-18 09:27:28","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=14344","menu_order":28,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28570,"post_author":"8","post_date":"2026-01-31 20:02:26","post_date_gmt":"2026-01-31 19:02:26","post_content":"<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-as2Mby\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Dorota Studzi\u0144ska, Sabina Licho\u0142ai, Kamil Polok, Hanna Plutecka, Piotr Kica, Piotr Grazda, Maciej Chwa\u0142a, Marek Sanak, Wojciech Szczeklik<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"20px\",\"epAnimationGeneratedClass\":\"edplus_anim-TLD5gM\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-LWwApb\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">The relationship between Th17-related immune mechanisms and miRNA regulation in the development of abdominal aortic aneurysm (AAA) is still not fully understood. This prospective study aimed to investigate the potential role of miR-21-5p in mediating Th17 pathway alterations contributing to AAA formation.<br>Samples were obtained from patients with infrarenal AAA undergoing elective open surgery and from a control group of peripheral arterial disease (PAD) patients without aneurysms, both at the time of surgical admission. Aneurysmal tissue fragments were collected intraoperatively. Total RNA was isolated, and miR-21-5p expression together with Th17-related markers were quantified using RT-qPCR and Luminex assays. Additionally, an in vitro model using human endothelial cells transfected with a synthetic miR-21-5p mimic was employed to study mechanistic effects.<br>A total of 60 participants were included\u201430 AAA cases and 30 matched controls. Circulating miR-21-5p levels were markedly elevated in AAA patients. Functional analysis revealed that miR-21-5p downregulates genes essential for endothelial development, vascular permeability regulation, and endothelial response to growth factors. Th17-associated cytokine levels were also increased in AAA patients and were particularly elevated in the midsection of the aneurysmal wall.<br><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-LWwApb\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">These findings suggest that elevated miR-21-5p contributes to endothelial dysfunction and inflammation, key processes driving the progression of abdominal aortic aneurysm.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"20px\",\"epAnimationGeneratedClass\":\"edplus_anim-TLD5gM\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-d0Kp5N\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: Abdominal aortic aneurysm, miR-21-5p, Th17 pathway, Interleukin 17A, Interleukin 21<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"20px\",\"epAnimationGeneratedClass\":\"edplus_anim-vDgWfZ\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-d0Kp5N\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Journal Issue: IJC Heart &amp; Vasculature<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-7ZR1O2\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Published by:<\/strong>\u00a0Elsevier<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"20px\",\"epAnimationGeneratedClass\":\"edplus_anim-vDgWfZ\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_697e520726a24\",\"name\":\"acf\/button\",\"data\":{\"title\":\"Read more\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352906725002246?via%3Dihub\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Role of miR-21-5p in the pathogenesis of abdominal aortic aneurysm regarding the Th17 pathway","post_excerpt":"Journal article:  IJC Heart & Vasculature, Published by: Elsevier, 2025","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"role-of-mir-21-5p-in-the-pathogenesis-of-abdominal-aortic-aneurysm-regarding-the-th17-pathway","to_ping":"","pinged":"","post_modified":"2026-01-31 20:04:20","post_modified_gmt":"2026-01-31 19:04:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=28570","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28592,"post_author":"8","post_date":"2026-01-31 20:14:34","post_date_gmt":"2026-01-31 19:14:34","post_content":"<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-0300LX\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Piotr Kica, Sabina Licho\u0142ai, Micha\u0142 Orzechowski, Maciej Malawski<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-cotKU2\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">Conference:\u00a0IEEE International Conference on Cluster Computing Workshops<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"20px\",\"epAnimationGeneratedClass\":\"edplus_anim-y0RYas\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_697e545904169\",\"name\":\"acf\/button\",\"data\":{\"title\":\"Read\/Download\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/arxiv.org\/pdf\/2409.05886\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Optimizing STAR Aligner for High Throughput Computing in the Cloud","post_excerpt":"Conference manuscript:  IEEE International Conference on Cluster Computing Workshops, 2024","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"optimizing-star-aligner-for-high-throughput-computing-in-the-cloud","to_ping":"","pinged":"","post_modified":"2026-01-31 20:15:39","post_modified_gmt":"2026-01-31 19:15:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&#038;p=28592","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"}]},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12281","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/people"}],"version-history":[{"count":6,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12281\/revisions"}],"predecessor-version":[{"id":28630,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12281\/revisions\/28630"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media\/13469"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=12281"}],"wp:term":[{"taxonomy":"people_teams","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people_teams?post=12281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}