{"id":12871,"date":"2023-07-14T14:47:06","date_gmt":"2023-07-14T12:47:06","guid":{"rendered":"https:\/\/new.sano.science\/?post_type=people&p=12871"},"modified":"2025-01-13T09:28:23","modified_gmt":"2025-01-13T08:28:23","slug":"karolina-tlalka","status":"publish","type":"people","link":"https:\/\/sano.science\/people\/karolina-tlalka\/","title":{"rendered":"Karolina Tla\u0142ka"},"excerpt":{"rendered":"

PhD Student in Extreme-scale Data and Computing<\/p>\n","protected":false},"featured_media":20290,"template":"","people_teams":[19,34],"class_list":["post-12871","people","type-people","status-publish","has-post-thumbnail","hentry","people_teams-research","people_teams-extreme-scale-data-and-computing"],"yoast_head":"\nKarolina Tla\u0142ka - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/people\/karolina-tlalka\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Karolina Tla\u0142ka\" \/>\n<meta property=\"og:description\" content=\"PhD Student in Extreme-scale Data and Computing\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/people\/karolina-tlalka\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-13T08:28:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sano.science\/wp-content\/uploads\/2023\/07\/Karolina-Tlalka-1024x1024.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/karolina-tlalka\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/people\\\/karolina-tlalka\\\/\",\"name\":\"Karolina Tla\u0142ka - 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Her areas of professional interest are models, cardiovascular system, CFD, control theory and machine learning. She joined Sano in July 2023 as a PhD student. Her PhD project focuses on 0D models of a cardiovascular system and regulation. In her free time, she sews or reads fantasy books.<\/p>\n","email":"","social_media":false,"tabs":false,"quote":"","position_with_team":{"text_before_link":"PhD Student in","link_text":"Extreme-scale Data Computing","text_after_link":"","link":"https:\/\/sano.science\/research-teams\/extreme-scale-data-and-computing\/"},"publications":[{"ID":20841,"post_author":"8","post_date":"2025-01-13 09:25:52","post_date_gmt":"2025-01-13 08:25:52","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-RWEf8c\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-karolina-tlalka-nbsp-harry-saxton-ian-halliday-xu-xu-andrew-narracott-daniel-taylor-maciej-malawski\">Karolina Tla\u0142ka , Harry Saxton, Ian Halliday, Xu Xu, Andrew Narracott, Daniel Taylor, Maciej Malawski<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-EFq7Vk\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-2RHCud\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">The baroreflex plays a crucial role in regulating the human cardiovascular system. This study employs a closed-loop in silico model of baroreflex control, integrated with pulsatile mechanical models featuring (i) a single heart chamber with 36 parameters and (ii) four chambers with 51 parameters. For the first time, a global sensitivity analysis is conducted on these closed-loop systems, accounting for both cardiovascular and baroreflex parameters. The results are compared with non-regulated versions of the models. Findings indicate that regulated parameters have a lower impact compared to non-regulated counterparts, and in a physiological resting state, outputs such as pressure, heart rate, and cardiac output are primarily influenced by parasympathetic arc parameters. This research enhances the understanding of regulation effects and parameter influence on clinical metrics, contributing to the development of personalized healthcare models.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-EFq7Vk\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-K67hWw\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: 10.1371\/journal.pcbi.1012377<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-kzZIS0\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: baroreflex, sensitivity analysis, cardiovascular system<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-EFq7Vk\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_6784cd51f8522\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1012377\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex","post_excerpt":"Journal paper: journals.plos.org, 2024","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sensitivity-analysis-of-closed-loop-one-chamber-and-four-chamber-models-with-baroreflex","to_ping":"","pinged":"","post_modified":"2025-01-13 12:27:51","post_modified_gmt":"2025-01-13 11:27:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&p=20841","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18615,"post_author":"8","post_date":"2024-08-13 15:46:49","post_date_gmt":"2024-08-13 13:46:49","post_content":"<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-dxa5g6\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-karolina-tlalka-harry-saxton-ian-halliday-xu-xu-daniel-taylor-andrew-narracott-maciej-malawski\">Karolina Tla\u0142ka, Harry Saxton, Ian Halliday, Xu Xu, Daniel Taylor, Andrew Narracott, Maciej Malawski<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"50px\",\"epAnimationGeneratedClass\":\"edplus_anim-iuxabp\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-N12jnw\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">In this study, the authors performed a local sensitivity analysis, a computationally inexpensive method of identifying influential parameters, supplemented with orthogonality analysis. A zero-dimensional closed-loop model with a one-chamber heart was analyzed in two versions - regulated in a rest state (with the representation of baroreflex proposed by Ursino in doi: 10.1152\/ajpheart.1998.275.5.H1733, but without any disturbance) and unregulated. Comparing results for the models, it is clear that the influence of baroreflex parameters is visibly smaller than cardiovascular (regulation set-point is the exception). Vagal activity dominates. The conclusion is that local sensitivity analysis may be successfully used to increase knowledge about the model and to validate it, but one must be aware of its limitations.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"30px\",\"epAnimationGeneratedClass\":\"edplus_anim-iuxabp\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-s6PQB6\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Authors<\/strong>: Karolina Tla\u0142ka, Harry Saxton, Ian Halliday, Xu Xu, Daniel Taylor, Andrew Narracott, Maciej Malawski<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-aKuwMF\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: <a href=\"https:\/\/doi.org\/10.1007\/978-3-031-63772-8_17\">doi.org\/10.1007\/978-3-031-63772-8_17<\/a><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-404zct\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: model development, sensitivity analysis, baroreflex<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"30px\",\"epAnimationGeneratedClass\":\"edplus_anim-iuxabp\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_6780e8fbc5551\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-031-63772-8_17\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation","post_excerpt":"conference manuscript: Springer, 2024","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation","to_ping":"","pinged":"","post_modified":"2025-02-05 11:51:39","post_modified_gmt":"2025-02-05 10:51:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&p=18615","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"}]},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/people"}],"version-history":[{"count":6,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12871\/revisions"}],"predecessor-version":[{"id":20849,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/12871\/revisions\/20849"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media\/20290"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=12871"}],"wp:term":[{"taxonomy":"people_teams","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people_teams?post=12871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}