{"id":24403,"date":"2025-06-29T22:13:53","date_gmt":"2025-06-29T20:13:53","guid":{"rendered":"https:\/\/sano.science\/?post_type=people&p=24403"},"modified":"2026-02-20T11:33:47","modified_gmt":"2026-02-20T10:33:47","slug":"alicja-wojciechowska","status":"publish","type":"people","link":"https:\/\/sano.science\/people\/alicja-wojciechowska\/","title":{"rendered":"Alicja Wojciechowska"},"excerpt":{"rendered":"

Junior Research Specialist<\/p>\n","protected":false},"featured_media":28241,"template":"","people_teams":[114],"class_list":["post-24403","people","type-people","status-publish","has-post-thumbnail","hentry","people_teams-structural-and-functional-genomics-group"],"yoast_head":"\nAlicja Wojciechowska - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/people\/alicja-wojciechowska\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alicja Wojciechowska\" \/>\n<meta property=\"og:description\" content=\"Junior Research Specialist\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/people\/alicja-wojciechowska\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-20T10:33:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sano.science\/wp-content\/uploads\/2025\/06\/Wojciechowska.png\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/alicja-wojciechowska\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/people\\\/alicja-wojciechowska\\\/\",\"name\":\"Alicja Wojciechowska - Centre for Computational Personalized Medicine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/alicja-wojciechowska\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/alicja-wojciechowska\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Wojciechowska.png\",\"datePublished\":\"2025-06-29T20:13:53+00:00\",\"dateModified\":\"2026-02-20T10:33:47+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/alicja-wojciechowska\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sano.science\\\/people\\\/alicja-wojciechowska\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/alicja-wojciechowska\\\/#primaryimage\",\"url\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Wojciechowska.png\",\"contentUrl\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Wojciechowska.png\",\"width\":800,\"height\":800},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sano.science\\\/people\\\/alicja-wojciechowska\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sano.science\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"People\",\"item\":\"https:\\\/\\\/sano.science\\\/people\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research\",\"item\":\"https:\\\/\\\/sano.science\\\/people-teams\\\/research\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Structural and Functional Genomics Group\",\"item\":\"https:\\\/\\\/sano.science\\\/people-teams\\\/structural-and-functional-genomics-group\\\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Alicja Wojciechowska\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sano.science\\\/#website\",\"url\":\"https:\\\/\\\/sano.science\\\/\",\"name\":\"Centre for Computational Personalized Medicine\",\"description\":\"Sano \u2013 Centre for Computational Medicine\",\"publisher\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sano.science\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/sano.science\\\/#organization\",\"name\":\"Sano \u2013 Centre for Computational Medicine\",\"alternateName\":\"Sano\",\"url\":\"https:\\\/\\\/sano.science\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sano.science\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/logo_sano_podstawowe.png\",\"contentUrl\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/logo_sano_podstawowe.png\",\"width\":700,\"height\":265,\"caption\":\"Sano \u2013 Centre for Computational Medicine\"},\"image\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/sano.science\\\/\",\"https:\\\/\\\/x.com\\\/sanoscience\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/sanoscience\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCDZ_8TcjMWUG2ZcgKKgfpwQ\",\"https:\\\/\\\/bsky.app\\\/profile\\\/sanoscience.bsky.social\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Alicja Wojciechowska - Centre for Computational Personalized Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sano.science\/people\/alicja-wojciechowska\/","og_locale":"en_US","og_type":"article","og_title":"Alicja Wojciechowska","og_description":"Junior Research Specialist","og_url":"https:\/\/sano.science\/people\/alicja-wojciechowska\/","og_site_name":"Centre for Computational Personalized Medicine","article_publisher":"https:\/\/www.facebook.com\/sano.science\/","article_modified_time":"2026-02-20T10:33:47+00:00","og_image":[{"width":800,"height":800,"url":"https:\/\/sano.science\/wp-content\/uploads\/2025\/06\/Wojciechowska.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_site":"@sanoscience","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sano.science\/people\/alicja-wojciechowska\/","url":"https:\/\/sano.science\/people\/alicja-wojciechowska\/","name":"Alicja Wojciechowska - Centre for Computational Personalized Medicine","isPartOf":{"@id":"https:\/\/sano.science\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sano.science\/people\/alicja-wojciechowska\/#primaryimage"},"image":{"@id":"https:\/\/sano.science\/people\/alicja-wojciechowska\/#primaryimage"},"thumbnailUrl":"https:\/\/sano.science\/wp-content\/uploads\/2025\/06\/Wojciechowska.png","datePublished":"2025-06-29T20:13:53+00:00","dateModified":"2026-02-20T10:33:47+00:00","breadcrumb":{"@id":"https:\/\/sano.science\/people\/alicja-wojciechowska\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sano.science\/people\/alicja-wojciechowska\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sano.science\/people\/alicja-wojciechowska\/#primaryimage","url":"https:\/\/sano.science\/wp-content\/uploads\/2025\/06\/Wojciechowska.png","contentUrl":"https:\/\/sano.science\/wp-content\/uploads\/2025\/06\/Wojciechowska.png","width":800,"height":800},{"@type":"BreadcrumbList","@id":"https:\/\/sano.science\/people\/alicja-wojciechowska\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sano.science\/"},{"@type":"ListItem","position":2,"name":"People","item":"https:\/\/sano.science\/people\/"},{"@type":"ListItem","position":3,"name":"Research","item":"https:\/\/sano.science\/people-teams\/research\/"},{"@type":"ListItem","position":4,"name":"Structural and Functional Genomics Group","item":"https:\/\/sano.science\/people-teams\/structural-and-functional-genomics-group\/"},{"@type":"ListItem","position":5,"name":"Alicja Wojciechowska"}]},{"@type":"WebSite","@id":"https:\/\/sano.science\/#website","url":"https:\/\/sano.science\/","name":"Centre for Computational Personalized Medicine","description":"Sano \u2013 Centre for Computational Medicine","publisher":{"@id":"https:\/\/sano.science\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sano.science\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/sano.science\/#organization","name":"Sano \u2013 Centre for Computational Medicine","alternateName":"Sano","url":"https:\/\/sano.science\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sano.science\/#\/schema\/logo\/image\/","url":"https:\/\/sano.science\/wp-content\/uploads\/2024\/05\/logo_sano_podstawowe.png","contentUrl":"https:\/\/sano.science\/wp-content\/uploads\/2024\/05\/logo_sano_podstawowe.png","width":700,"height":265,"caption":"Sano \u2013 Centre for Computational Medicine"},"image":{"@id":"https:\/\/sano.science\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/sano.science\/","https:\/\/x.com\/sanoscience","https:\/\/www.linkedin.com\/company\/sanoscience\/","https:\/\/www.youtube.com\/channel\/UCDZ_8TcjMWUG2ZcgKKgfpwQ","https:\/\/bsky.app\/profile\/sanoscience.bsky.social"]}]}},"acf":[],"meta_data":{"description":"<p>Alicja is a bioinformatician that aims to tell stories by analysing biological data. She holds Master diplomas from Wroclaw University of Science and Technology in Bioinformatics and Big Data Analytics and is finishing her PhD there. The particular focus of her PhD thesis were microbial proteins secreted by our gut bacteria and their role in neurodegeneration. Apart from that, Alicja has worked on various topics including virus mutations and epidemics spread, pathogenesis of carribean brain-eating amoeba and analysis of protein structures and sequences. Currently, she focuses on interdisciplinary analysis of microbiome data. Privately, she enjoys good tea accopmanied by a long boardgame.<\/p>\n","email":"","position_with_team":{"text_before_link":"Junior Research Specialist in","link_text":"Structural and Functional Genomics Group","text_after_link":"","link":"https:\/\/sano.science\/research-teams\/structural-and-functional-genomics\/"},"social_media":false,"tabs":false,"quote":"","publications":[{"ID":20667,"post_author":"8","post_date":"2025-01-10 11:32:20","post_date_gmt":"2025-01-10 10:32:20","post_content":"<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-fO7P2F\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:heading {\"epAnimationGeneratedClass\":\"edplus_anim-nIXyqz\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-guerlais-v-allouch-n-moseman-e-a-wojciechowska-a-w-wojciechowski-j-w-marcelino-i\">Guerlais, V., Allouch, N., Moseman, E. A., Wojciechowska, A. W., Wojciechowski, J. W., Marcelino, I<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-fO7P2F\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-0BKizZ\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\">The free-living amoeba <em>Naegleria fowleri<\/em> (NF) causes a rare but deadly parasitic meningoencephalitis (PAM) in humans, with no effective treatments available. The molecular mechanisms behind NF pathogenesis and the host brain response remain unclear. To investigate natural virulence variation, two new environmental NF isolates (NF45 and NF1) were purified and tested for in vivo virulence in mice. NF45 exhibited high virulence (NF45_HV) compared to the lower virulence NF1 (NF1_LV), based on amoeba growth and mouse survival rates. RNA-seq analysis of infected mouse brains revealed differential gene expression patterns: NF1_LV upregulated genes related to translational proteins and protein modification, while NF45_HV modulated genes associated with DNA metabolism and cytoskeletal proteins. The virulence factor Cathepsin B was upregulated in NF1_LV but downregulated in NF45_HV. Host response analysis indicated stronger immune activation in NF1_LV infections, including blood-brain barrier leakage, immune cell recruitment, cytokine release (IL-6, IFN-\u0194, TNF\u03b1), and neuronal damage. Neuromotor-related genes (Adam22, Cacnb4, Zic1 for NF1_LV and ChAt for NF45_HV) were linked to PAM symptoms like muscle weakness and seizures. The study highlights the varying virulence of environmental NF strains and their distinct effects on gene expression during infection, providing the first comprehensive insight into the molecular mechanisms of PAM pathogenesis. Targeting both the parasite and the host could be a promising approach for future PAM therapies.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-fO7P2F\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-f828Q4\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: https:\/\/doi.org\/10.3389\/fcimb.2024.1490280<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph {\"epAnimationGeneratedClass\":\"edplus_anim-bG62C7\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<p class=\" eplus-wrapper\"><strong>Keywords:<\/strong> Naegleria fowleri, virulence phenotypes, mouse brain infection, RNA-seq analysis, neuroinflammation, host-parasite interaction, neurodegeneration, differentially expressed genes (DEGs)<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:spacer {\"height\":\"40px\",\"epAnimationGeneratedClass\":\"edplus_anim-fO7P2F\",\"epGeneratedClass\":\"eplus-wrapper\"} -->\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:acf\/button {\"id\":\"block_6780f71be7fb8\",\"name\":\"acf\/button\",\"data\":{\"title\":\"READ HERE\",\"_title\":\"field_61d40397c2f0a\",\"button_type\":\"link\",\"_button_type\":\"field_63bbde3b8f0d0\",\"url\":\"https:\/\/www.frontiersin.org\/journals\/cellular-and-infection-microbiology\/articles\/10.3389\/fcimb.2024.1490280\/full\",\"_url\":\"field_61d4039bc2f0b\",\"button_style\":\"primary\",\"_button_style\":\"field_63872d045d0f0\",\"target\":\"_self\",\"_target\":\"field_63872c705d0ef\",\"button_extra_classes\":\"\",\"_button_extra_classes\":\"field_642beab6a97de\"},\"align\":\"\",\"mode\":\"edit\"} \/-->","post_title":"Transcriptomic profiling of \u201cbrain-eating amoeba\u201d Naegleria fowleri infection in mice: the host and the protozoa perspectives","post_excerpt":"Journal paper in: www.frontiersin.org, 2024","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"transcriptomic-profiling-of-brain-eating-amoeba-naegleria-fowleri-infection-in-mice-the-host-and-the-protozoa-perspectives","to_ping":"","pinged":"","post_modified":"2025-01-13 13:36:45","post_modified_gmt":"2025-01-13 12:36:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/sano.science\/?post_type=research&p=20667","menu_order":0,"post_type":"research","post_mime_type":"","comment_count":"0","filter":"raw"}]},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/24403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/people"}],"version-history":[{"count":6,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/24403\/revisions"}],"predecessor-version":[{"id":29238,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people\/24403\/revisions\/29238"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media\/28241"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=24403"}],"wp:term":[{"taxonomy":"people_teams","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/people_teams?post=24403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}