{"id":25859,"date":"2025-09-03T17:21:25","date_gmt":"2025-09-03T15:21:25","guid":{"rendered":"https:\/\/sano.science\/?p=25859"},"modified":"2025-10-27T12:35:10","modified_gmt":"2025-10-27T11:35:10","slug":"sano-researchers-co-create-ai-powered-platform-to-explore-protein-structures","status":"publish","type":"post","link":"https:\/\/sano.science\/sano-researchers-co-create-ai-powered-platform-to-explore-protein-structures\/","title":{"rendered":"Sano researchers co-create AI-powered platform to explore protein structures"},"content":{"rendered":"\n

Scientists from Sano Centre for Computational Medicine have co-authored research that combines artificial intelligence with protein biology to accelerate discoveries in medicine. The work, published in Nature Communications, presents a new interactive online platform that organizes the world\u2019s largest datasets of protein structures and makes them accessible to the global scientific community.<\/p>\n\n\n\n

A tool for exploring the landscape of proteins<\/h2>\n\n\n\n

The new platform \u2013 available at protein-structure-landscape.sano.science \u2013 enables researchers to visually explore and analyze nearly one billion predicted protein structures. By integrating data from three of the largest resources \u2013 AlphaFold (awarded the 2024 Nobel Prize in Chemistry), ESMAtlas, and the Microbiome Immunity Project \u2013 the tool provides a unified \u201cmap\u201d of protein space.<\/p>\n\n\n\n

\n

\u201cOur goal was not only to organize these massive datasets but also to create a resource that helps us better understand protein biology,\u201d explains Dr. Tomasz Ko\u015bcio\u0142ek<\/a>, co-author of the study and leader of the Structural and Functional Genomics team at Sano.<\/p>\n<\/blockquote>\n\n\n\n

The team demonstrated that proteins with similar biological functions often cluster together in the data landscape \u2013 a phenomenon they call \u201cfunctional locality.\u201d<\/p>\n\n\n\n

AI methods reveal hidden protein functions<\/h2>\n\n\n\n

In addition to mapping the known data, the researchers applied advanced AI methods such as deepFRI, which can predict protein functions even when their sequences differ from previously characterized examples. This approach allowed the discovery of previously unknown variants, including proteins potentially involved in lipid transport or biochemical processes in extreme environments.<\/p>\n\n\n\n

\n

\u201cWe believe our platform will contribute to the development of better diagnostic and therapeutic methods, while also helping us understand molecular life at the structural level,\u201d says Dr. Pawe\u0142 Szczerbiak<\/a>, first author of the study and researcher at Sano.<\/p>\n<\/blockquote>\n\n\n\n

An international collaboration led from Krakow<\/h2>\n\n\n\n

The project was developed in collaboration with Jagiellonian University, the Flatiron Institute (USA), and the Open Molecular Software Foundation (USA).<\/p>\n\n\n\n

Global impact and open access<\/h2>\n\n\n\n

The platform is freely available to scientists around the world. It can be used for microbiome research, studies on protein evolution, and in the design of new drugs and therapies. Its intuitive, visual interface also makes it a valuable educational tool for students and young researchers.<\/p>\n\n\n\n

\u2e3b<\/p>\n\n\n\n

\ud83d\udd17 Read the full publication in Nature Communications: https:\/\/www.nature.com\/articles\/s41467-025-63250-3
\ud83d\udd17 Explore the interactive protein map<\/strong>: protein-structure-landscape.sano.science<\/strong><\/a><\/p>\n\n\n\n

Congratulations to our Sano team \u2013 Dr. Tomasz Ko\u015bcio\u0142ek, Dr. Pawe\u0142 Szczerbiak \u2013 and all collaborators!<\/h4>\n\n\n\n

<\/p>\n","protected":false},"excerpt":"Scientists from Sano Centre for Computational Medicine have co-authored research that combines artificial intelligence with protein biology to accelerate discoveries in medicine. The work, published in Nature Communications, presents a new interactive online platform that organizes the world\u2019s largest datasets of protein structures and makes them accessible to the global scientific community. A tool for […]","author":8,"featured_media":25861,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"editor_plus_post_options":"{}","editor_plus_copied_stylings":"{}","footnotes":""},"categories":[1],"tags":[],"class_list":["post-25859","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nSano researchers co-create AI-powered platform to explore protein structures - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/sano-researchers-co-create-ai-powered-platform-to-explore-protein-structures\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sano researchers co-create AI-powered platform to explore protein structures\" \/>\n<meta property=\"og:description\" content=\"Scientists from Sano Centre for Computational Medicine have co-authored research that combines artificial intelligence with protein biology to accelerate discoveries in medicine. The work, published in Nature Communications, presents a new interactive online platform that organizes the world\u2019s largest datasets of protein structures and makes them accessible to the global scientific community. 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The work, published in Nature Communications, presents a new interactive online platform that organizes the world\u2019s largest datasets of protein structures and makes them accessible to the global scientific community.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Scientists from Sano Centre for Computational Medicine have co-authored research that combines artificial intelligence with protein biology to accelerate discoveries in medicine. The work, published in Nature Communications, presents a new interactive online platform that organizes the world\u2019s largest datasets of protein structures and makes them accessible to the global scientific community.<\/p>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-UkCdDc","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-a-tool-for-exploring-the-landscape-of-proteins\">A tool for exploring the landscape of proteins<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-a-tool-for-exploring-the-landscape-of-proteins\">A tool for exploring the landscape of proteins<\/h2>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-WHIj4B","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">The new platform \u2013 available at protein-structure-landscape.sano.science \u2013 enables researchers to visually explore and analyze nearly one billion predicted protein structures. By integrating data from three of the largest resources \u2013 AlphaFold (awarded the 2024 Nobel Prize in Chemistry), ESMAtlas, and the Microbiome Immunity Project \u2013 the tool provides a unified \u201cmap\u201d of protein space.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">The new platform \u2013 available at protein-structure-landscape.sano.science \u2013 enables researchers to visually explore and analyze nearly one billion predicted protein structures. By integrating data from three of the largest resources \u2013 AlphaFold (awarded the 2024 Nobel Prize in Chemistry), ESMAtlas, and the Microbiome Immunity Project \u2013 the tool provides a unified \u201cmap\u201d of protein space.<\/p>\n"]},{"blockName":"core\/quote","attrs":{"epAnimationGeneratedClass":"edplus_anim-4YSUDf","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-4lVbPp","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">\u201cOur goal was not only to organize these massive datasets but also to create a resource that helps us better understand protein biology,\u201d explains <a href=\"https:\/\/sano.science\/people\/tomasz-kosciolek\/\">Dr. Tomasz Ko\u015bcio\u0142ek<\/a>, co-author of the study and leader of the Structural and Functional Genomics team at Sano.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">\u201cOur goal was not only to organize these massive datasets but also to create a resource that helps us better understand protein biology,\u201d explains <a href=\"https:\/\/sano.science\/people\/tomasz-kosciolek\/\">Dr. Tomasz Ko\u015bcio\u0142ek<\/a>, co-author of the study and leader of the Structural and Functional Genomics team at Sano.<\/p>\n"]}],"innerHTML":"\n<blockquote class=\"wp-block-quote eplus-wrapper\"><\/blockquote>\n","innerContent":["\n<blockquote class=\"wp-block-quote eplus-wrapper\">",null,"<\/blockquote>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-sh5AYl","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">The team demonstrated that proteins with similar biological functions often cluster together in the data landscape \u2013 a phenomenon they call \u201cfunctional locality.\u201d<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">The team demonstrated that proteins with similar biological functions often cluster together in the data landscape \u2013 a phenomenon they call \u201cfunctional locality.\u201d<\/p>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-VH5WiC","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-ai-methods-reveal-hidden-protein-functions\">AI methods reveal hidden protein functions<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-ai-methods-reveal-hidden-protein-functions\">AI methods reveal hidden protein functions<\/h2>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-zaWYNZ","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">In addition to mapping the known data, the researchers applied advanced AI methods such as deepFRI, which can predict protein functions even when their sequences differ from previously characterized examples. This approach allowed the discovery of previously unknown variants, including proteins potentially involved in lipid transport or biochemical processes in extreme environments.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">In addition to mapping the known data, the researchers applied advanced AI methods such as deepFRI, which can predict protein functions even when their sequences differ from previously characterized examples. This approach allowed the discovery of previously unknown variants, including proteins potentially involved in lipid transport or biochemical processes in extreme environments.<\/p>\n"]},{"blockName":"core\/quote","attrs":{"epAnimationGeneratedClass":"edplus_anim-sVzMnh","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-UgMFwt","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">\u201cWe believe our platform will contribute to the development of better diagnostic and therapeutic methods, while also helping us understand molecular life at the structural level,\u201d says <a href=\"https:\/\/sano.science\/people\/pawel-szczerbiak\/\">Dr. Pawe\u0142 Szczerbiak<\/a>, first author of the study and researcher at Sano.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">\u201cWe believe our platform will contribute to the development of better diagnostic and therapeutic methods, while also helping us understand molecular life at the structural level,\u201d says <a href=\"https:\/\/sano.science\/people\/pawel-szczerbiak\/\">Dr. Pawe\u0142 Szczerbiak<\/a>, first author of the study and researcher at Sano.<\/p>\n"]}],"innerHTML":"\n<blockquote class=\"wp-block-quote eplus-wrapper\"><\/blockquote>\n","innerContent":["\n<blockquote class=\"wp-block-quote eplus-wrapper\">",null,"<\/blockquote>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-juEZdn","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-an-international-collaboration-led-from-krakow\">An international collaboration led from Krakow<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-an-international-collaboration-led-from-krakow\">An international collaboration led from Krakow<\/h2>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-eDhahM","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">The project was developed in collaboration with Jagiellonian University, the Flatiron Institute (USA), and the Open Molecular Software Foundation (USA).<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">The project was developed in collaboration with Jagiellonian University, the Flatiron Institute (USA), and the Open Molecular Software Foundation (USA).<\/p>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-6ECp1U","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-global-impact-and-open-access\">Global impact and open access<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-global-impact-and-open-access\">Global impact and open access<\/h2>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-dRzj4R","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">The platform is freely available to scientists around the world. It can be used for microbiome research, studies on protein evolution, and in the design of new drugs and therapies. Its intuitive, visual interface also makes it a valuable educational tool for students and young researchers.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">The platform is freely available to scientists around the world. It can be used for microbiome research, studies on protein evolution, and in the design of new drugs and therapies. Its intuitive, visual interface also makes it a valuable educational tool for students and young researchers.<\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-1WoGiw","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">\u2e3b<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">\u2e3b<\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-AzjI9f","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">\ud83d\udd17 Read the full publication in Nature Communications: https:\/\/www.nature.com\/articles\/s41467-025-63250-3<br>\ud83d\udd17 Explore the <strong>interactive protein map<\/strong>: <a href=\"https:\/\/protein-structure-landscape.sano.science\/\"><strong>protein-structure-landscape.sano.science<\/strong><\/a><\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">\ud83d\udd17 Read the full publication in Nature Communications: https:\/\/www.nature.com\/articles\/s41467-025-63250-3<br>\ud83d\udd17 Explore the <strong>interactive protein map<\/strong>: <a href=\"https:\/\/protein-structure-landscape.sano.science\/\"><strong>protein-structure-landscape.sano.science<\/strong><\/a><\/p>\n"]},{"blockName":"core\/heading","attrs":{"level":4,"epAnimationGeneratedClass":"edplus_anim-l4BCyz","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h4 class=\"wp-block-heading eplus-wrapper\" id=\"h-congratulations-to-our-sano-team-dr-tomasz-kosciolek-dr-pawel-szczerbiak-and-all-collaborators\">Congratulations to our Sano team \u2013 Dr. Tomasz Ko\u015bcio\u0142ek, Dr. Pawe\u0142 Szczerbiak \u2013 and all collaborators!<\/h4>\n","innerContent":["\n<h4 class=\"wp-block-heading eplus-wrapper\" id=\"h-congratulations-to-our-sano-team-dr-tomasz-kosciolek-dr-pawel-szczerbiak-and-all-collaborators\">Congratulations to our Sano team \u2013 Dr. Tomasz Ko\u015bcio\u0142ek, Dr. Pawe\u0142 Szczerbiak \u2013 and all collaborators!<\/h4>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-w80WyH","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><\/p>\n"]}],"meta_data":{"has_thumbnail_pattern":false,"share_on_social_media":{"has_social_media":false}},"featured_image":{"url":"https:\/\/sano.science\/wp-content\/uploads\/2025\/09\/Sano-researchers-co-create-AI-powered-platform-to-explore-protein-structures-1024x573.jpg"},"main_category":{"name":"Uncategorized"},"prev_page":{"slug":"sano-x-cluster-breakfast-how-digital-twins-are-changing-clinical-decision%e2%80%91making"},"next_page":{"slug":"digital-twin-in-practice-breakfast-of-klaster-life-science-krakow-hosted-by-sano"},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/posts\/25859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/comments?post=25859"}],"version-history":[{"count":3,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/posts\/25859\/revisions"}],"predecessor-version":[{"id":26505,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/posts\/25859\/revisions\/26505"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media\/25861"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=25859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/categories?post=25859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/tags?post=25859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}