{"id":28376,"date":"2026-01-27T16:15:00","date_gmt":"2026-01-27T15:15:00","guid":{"rendered":"https:\/\/sano.science\/?p=28376"},"modified":"2026-01-30T10:03:49","modified_gmt":"2026-01-30T09:03:49","slug":"oligomerization-of-rna-binding-proteins-mechanism-unveiled","status":"publish","type":"post","link":"https:\/\/sano.science\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\/","title":{"rendered":"Oligomerization of RNA Binding Proteins: Mechanism Unveiled"},"content":{"rendered":"\n

At Sano Centre for Computational Medicine, we track breakthroughs in computational medicine, including research on mechanisms on protein aggreagation. The new article \u201cMechanism of ribonucleoprotein low complexity domain molecule oligomerization: Experimental investigations and theoretical modeling<\/a>\u201d by Paulina \u017beliszewska, Pooja Shah, Kamil Rakowski, Jakub W. Wojciechowski<\/a> (from our Sano team), Aleksandra Wosztyl, Anna Kluza, Aneta Michna, Zbigniew Adamczyk, and Anna Bratek-Skicki sheds light on a key challenge.<\/p>\n\n\n\n

Problem: Unknown Oligomerization Mechanism<\/h2>\n\n\n\n

Nucleation of RNA-binding proteins is the first step in forming functional RNA-protein complexes (RNPs) that regulate RNA metabolism. But sometimes things can go wrong. Mutations in such protein can lead to severe neurodegenerative disorders like Amyotrophic lateral sclerosis and other forms of dementia. This study focuses on the low complexity domain (LCD) of heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) \u2013 a key player in RNA metabolism \u2013 whose oligomerization mechanism was poorly understood.<\/p>\n\n\n\n

Solution: Experiments and Modeling<\/h2>\n\n\n\n

The authors combined experimental and theoretical techniques to better understand early stages of hnRNPA2 LCD aggregation in different ionic strengths and pH. They developed a new method of studying oligomerization stage using techniques adopted from material science and chemical engineering. Experiments were supported by Molecular dynamics modeling which provided atomic-level insight into pH driven conformational changes and their role in oligomerization.<\/p>\n\n\n\n

Significance for Science and Medicine<\/h2>\n\n\n\n

Beyond basic research contributions, the results enabled development of an effective method for quantifying oligomerization kinetics in unstable protein solutions. The work highlights the role of computational modeling in understanding protein pathologies, aligning with Sano\u2019s mission in personalized medicine.<\/p>\n","protected":false},"excerpt":"\u201cWhy does my protein make jelly and how is it related to neurodegeneration? \u201cJakub Wojciechowski","author":8,"featured_media":28380,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"editor_plus_post_options":"{}","editor_plus_copied_stylings":"{}","footnotes":""},"categories":[1],"tags":[],"class_list":["post-28376","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nOligomerization of RNA Binding Proteins: Mechanism Unveiled - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oligomerization of RNA Binding Proteins: Mechanism Unveiled\" \/>\n<meta property=\"og:description\" content=\"\u201cWhy does my protein make jelly and how is it related to neurodegeneration? \u201cJakub Wojciechowski\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-27T15:15:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-30T09:03:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sano.science\/wp-content\/uploads\/2026\/01\/publikacja-Jakub-Wojciechowski-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"2033\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sano\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sano\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sano.science\\\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sano.science\\\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\\\/\"},\"author\":{\"name\":\"Sano\",\"@id\":\"https:\\\/\\\/sano.science\\\/#\\\/schema\\\/person\\\/561b69b48b6a8f7904aed06df5d03c98\"},\"headline\":\"Oligomerization of RNA Binding Proteins: Mechanism Unveiled\",\"datePublished\":\"2026-01-27T15:15:00+00:00\",\"dateModified\":\"2026-01-30T09:03:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sano.science\\\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\\\/\"},\"wordCount\":257,\"publisher\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/sano.science\\\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/publikacja-Jakub-Wojciechowski-scaled.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/oligomerization-of-rna-binding-proteins-mechanism-unveiled\\\/\",\"name\":\"Oligomerization of RNA Binding Proteins: Mechanism Unveiled - 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The new article \u201c<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S014181302510487X\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Mechanism of ribonucleoprotein low complexity domain molecule oligomerization: Experimental investigations and theoretical modeling<\/a>\u201d by Paulina \u017beliszewska, Pooja Shah, Kamil Rakowski, <a href=\"https:\/\/sano.science\/people\/jakub-wojciechowski\/\" type=\"people\" id=\"15540\">Jakub W. Wojciechowski<\/a> (from our Sano team), Aleksandra Wosztyl, Anna Kluza, Aneta Michna, Zbigniew Adamczyk, and Anna Bratek-Skicki sheds light on a key challenge.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">At Sano Centre for Computational Medicine, we track breakthroughs in computational medicine, including research on mechanisms on protein aggreagation. The new article \u201c<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S014181302510487X\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Mechanism of ribonucleoprotein low complexity domain molecule oligomerization: Experimental investigations and theoretical modeling<\/a>\u201d by Paulina \u017beliszewska, Pooja Shah, Kamil Rakowski, <a href=\"https:\/\/sano.science\/people\/jakub-wojciechowski\/\" type=\"people\" id=\"15540\">Jakub W. Wojciechowski<\/a> (from our Sano team), Aleksandra Wosztyl, Anna Kluza, Aneta Michna, Zbigniew Adamczyk, and Anna Bratek-Skicki sheds light on a key challenge.<\/p>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-gL0qvh","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-problem-unknown-oligomerization-mechanism\">Problem: Unknown Oligomerization Mechanism<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-problem-unknown-oligomerization-mechanism\">Problem: Unknown Oligomerization Mechanism<\/h2>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-dvYFkY","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">Nucleation of RNA-binding proteins is the first step in forming functional RNA-protein complexes (RNPs) that regulate RNA metabolism. But sometimes things can go wrong. Mutations in such protein can lead to severe neurodegenerative disorders like Amyotrophic lateral sclerosis and other forms of dementia. This study focuses on the low complexity domain (LCD) of heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) \u2013 a key player in RNA metabolism \u2013 whose oligomerization mechanism was poorly understood.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Nucleation of RNA-binding proteins is the first step in forming functional RNA-protein complexes (RNPs) that regulate RNA metabolism. But sometimes things can go wrong. Mutations in such protein can lead to severe neurodegenerative disorders like Amyotrophic lateral sclerosis and other forms of dementia. This study focuses on the low complexity domain (LCD) of heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) \u2013 a key player in RNA metabolism \u2013 whose oligomerization mechanism was poorly understood.<\/p>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-VZePV8","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-solution-experiments-and-modeling\">Solution: Experiments and Modeling<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-solution-experiments-and-modeling\">Solution: Experiments and Modeling<\/h2>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-py2RsU","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">The authors combined experimental and theoretical techniques to better understand early stages of hnRNPA2 LCD aggregation in different ionic strengths and pH. They developed a new method of studying oligomerization stage using techniques adopted from material science and chemical engineering. Experiments were supported by Molecular dynamics modeling which provided atomic-level insight into pH driven conformational changes and their role in oligomerization.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">The authors combined experimental and theoretical techniques to better understand early stages of hnRNPA2 LCD aggregation in different ionic strengths and pH. They developed a new method of studying oligomerization stage using techniques adopted from material science and chemical engineering. Experiments were supported by Molecular dynamics modeling which provided atomic-level insight into pH driven conformational changes and their role in oligomerization.<\/p>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-ok9dTd","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-significance-for-science-and-medicine\">Significance for Science and Medicine<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-significance-for-science-and-medicine\">Significance for Science and Medicine<\/h2>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-5xLgQV","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">Beyond basic research contributions, the results enabled development of an effective method for quantifying oligomerization kinetics in unstable protein solutions. The work highlights the role of computational modeling in understanding protein pathologies, aligning with Sano\u2019s mission in personalized medicine.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Beyond basic research contributions, the results enabled development of an effective method for quantifying oligomerization kinetics in unstable protein solutions. The work highlights the role of computational modeling in understanding protein pathologies, aligning with Sano\u2019s mission in personalized medicine.<\/p>\n"]}],"meta_data":{"has_thumbnail_pattern":false,"share_on_social_media":{"has_social_media":false}},"featured_image":{"url":"https:\/\/sano.science\/wp-content\/uploads\/2026\/01\/publikacja-Jakub-Wojciechowski-1024x813.jpg"},"main_category":{"name":"Uncategorized"},"prev_page":{"slug":"memorandum-of-understanding-between-mbru-and-sano"},"next_page":{"slug":"our-latest-newsletter"},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/posts\/28376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/comments?post=28376"}],"version-history":[{"count":2,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/posts\/28376\/revisions"}],"predecessor-version":[{"id":28381,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/posts\/28376\/revisions\/28381"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media\/28380"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=28376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/categories?post=28376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/tags?post=28376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}