{"id":32028,"date":"2026-07-20T12:14:57","date_gmt":"2026-07-20T10:14:57","guid":{"rendered":"https:\/\/sano.science\/?p=32028"},"modified":"2026-07-20T12:15:07","modified_gmt":"2026-07-20T10:15:07","slug":"sanos-deepfri2-at-ismb-2026","status":"publish","type":"post","link":"https:\/\/sano.science\/sanos-deepfri2-at-ismb-2026\/","title":{"rendered":"Sano&#8217;s deepFRI2 at ISMB 2026\u00a0"},"content":{"rendered":"\n<p class=\"eplus-wrapper wp-block-paragraph\">Sano was represented at an important international conference in computational biology this July, as <a href=\"https:\/\/sano.science\/people\/pawel-szczerbiak\/\" data-type=\"people\" data-id=\"15449\">Pawe\u0142 Szczerbiak<\/a>, a postdoctoral researcher in Sano&#8217;s Structural and Functional Genomics Group, took the stage at the 34th Conference on Intelligent Systems for Molecular Biology (ISMB 2026).<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Held from 12 to 16 July at the Washington Hilton in Washington, D.C., ISMB is the flagship meeting of the International Society for Computational Biology (ISCB). This year the conference returned to the city where ISCB and ISMB were founded back in 1993, drawing more than 2,000 computational life scientists from around the world. Pawe\u0142 Szczerbiak presented both a poster and a flash talk titled &#8220;Interpretable protein function predictions with deepFRI2.&#8221;<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">deepFRI2 is an upgraded framework for predicting the biological function of proteins directly from their sequence and structure. What sets it apart is its focus on interpretability: instead of behaving like a &#8220;black box,&#8221; the model points to the specific regions of a protein that drive a given functional prediction. Remarkably, it reaches state-of-the-art accuracy using only a few million parameters, making it both efficient and scalable \u2014 qualities that matter increasingly as researchers apply artificial intelligence to a vast and fast-growing catalogue of protein structures.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">For Szczerbiak, the conference was as much about listening as presenting. He singled out the keynote by Marinka Zitnik of Harvard Medical School \u2014 an \u201cextraordinary\u201d talk on AI-driven discovery in medicine \u2014 as a personal highlight, noting how sharply the field has advanced in just one year, in step with the rapid progress of language models. Meetings of this scale, he added, are an invaluable chance to map the frontiers of bioinformatics, exchange ideas, and stay current with the trends shaping the discipline.<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n<div class=\"wp-block-columns eplus-wrapper is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex eplus-styles-uid-5d2aa0\">\n<div class=\"wp-block-column eplus-wrapper is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-large eplus-wrapper\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"1024\" src=\"https:\/\/sano.science\/wp-content\/uploads\/2026\/07\/Pawel-Szczerbiak-Sanos-deepFRI2-at-ISMB-2026--768x1024.jpg\" alt=\"\" class=\"wp-image-32074\" srcset=\"https:\/\/sano.science\/wp-content\/uploads\/2026\/07\/Pawel-Szczerbiak-Sanos-deepFRI2-at-ISMB-2026--768x1024.jpg 768w, https:\/\/sano.science\/wp-content\/uploads\/2026\/07\/Pawel-Szczerbiak-Sanos-deepFRI2-at-ISMB-2026--225x300.jpg 225w, https:\/\/sano.science\/wp-content\/uploads\/2026\/07\/Pawel-Szczerbiak-Sanos-deepFRI2-at-ISMB-2026--1152x1536.jpg 1152w, https:\/\/sano.science\/wp-content\/uploads\/2026\/07\/Pawel-Szczerbiak-Sanos-deepFRI2-at-ISMB-2026-.jpg 1536w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column eplus-wrapper is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"eplus-wrapper wp-block-paragraph\">The deepFRI2\u00a0project\u00a0was\u00a0also\u00a0the\u00a0subject\u00a0of a\u00a0recent\u00a0Sano\u00a0Seminar, &#8220;Interpretable protein function predictions with deepFRI2,&#8221; for anyone who would like to explore the\u00a0work\u00a0in\u00a0more\u00a0depth\u00a0(<a href=\"https:\/\/sano.science\/seminars\/interpretable-protein-function-predictions-with-deepfri2\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/interpretable-protein-function-predictions-with-deepfri2<\/a>).\u00a0<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Sano&#8217;s presence at ISMB 2026 underscores the institute&#8217;s growing role in the international computational medicine community \u2014 and its commitment to developing AI tools that are not only powerful, but also transparent and trustworthy.<\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":"Postdoctoral researcher Pawe\u0142 Szczerbiak presented Sano's interpretable protein-function prediction model to more than 2,000 computational biologists in Washington, D.C ","author":8,"featured_media":32081,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"editor_plus_post_options":"{}","editor_plus_copied_stylings":"{}","footnotes":""},"categories":[1],"tags":[],"class_list":["post-32028","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sano&#039;s deepFRI2 at ISMB 2026\u00a0 - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"description\" content=\"Sano&#039;s Pawe\u0142 Szczerbiak presented deepFRI2, an interpretable AI model for protein function prediction, at ISMB 2026 in Washington, D.C.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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class=\" eplus-wrapper\">Sano was represented at an important international conference in computational biology this July, as <a href=\"https:\/\/sano.science\/people\/pawel-szczerbiak\/\" data-type=\"people\" data-id=\"15449\">Pawe\u0142 Szczerbiak<\/a>, a postdoctoral researcher in Sano's Structural and Functional Genomics Group, took the stage at the 34th Conference on Intelligent Systems for Molecular Biology (ISMB 2026).<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Sano was represented at an important international conference in computational biology this July, as <a href=\"https:\/\/sano.science\/people\/pawel-szczerbiak\/\" data-type=\"people\" data-id=\"15449\">Pawe\u0142 Szczerbiak<\/a>, a postdoctoral researcher in Sano's Structural and Functional Genomics Group, took the stage at the 34th Conference on Intelligent Systems for Molecular Biology (ISMB 2026).<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"10px","epAnimationGeneratedClass":"edplus_anim-AyIYj1","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-YboY8M","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">Held from 12 to 16 July at the Washington Hilton in Washington, D.C., ISMB is the flagship meeting of the International Society for Computational Biology (ISCB). This year the conference returned to the city where ISCB and ISMB were founded back in 1993, drawing more than 2,000 computational life scientists from around the world. Pawe\u0142 Szczerbiak presented both a poster and a flash talk titled \"Interpretable protein function predictions with deepFRI2.\"<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Held from 12 to 16 July at the Washington Hilton in Washington, D.C., ISMB is the flagship meeting of the International Society for Computational Biology (ISCB). This year the conference returned to the city where ISCB and ISMB were founded back in 1993, drawing more than 2,000 computational life scientists from around the world. Pawe\u0142 Szczerbiak presented both a poster and a flash talk titled \"Interpretable protein function predictions with deepFRI2.\"<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"10px","epAnimationGeneratedClass":"edplus_anim-AyIYj1","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-j58cnI","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">deepFRI2 is an upgraded framework for predicting the biological function of proteins directly from their sequence and structure. What sets it apart is its focus on interpretability: instead of behaving like a \"black box,\" the model points to the specific regions of a protein that drive a given functional prediction. Remarkably, it reaches state-of-the-art accuracy using only a few million parameters, making it both efficient and scalable \u2014 qualities that matter increasingly as researchers apply artificial intelligence to a vast and fast-growing catalogue of protein structures.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">deepFRI2 is an upgraded framework for predicting the biological function of proteins directly from their sequence and structure. What sets it apart is its focus on interpretability: instead of behaving like a \"black box,\" the model points to the specific regions of a protein that drive a given functional prediction. Remarkably, it reaches state-of-the-art accuracy using only a few million parameters, making it both efficient and scalable \u2014 qualities that matter increasingly as researchers apply artificial intelligence to a vast and fast-growing catalogue of protein structures.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"10px","epAnimationGeneratedClass":"edplus_anim-AyIYj1","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-B4854z","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">For Szczerbiak, the conference was as much about listening as presenting. He singled out the keynote by Marinka Zitnik of Harvard Medical School \u2014 an \u201cextraordinary\u201d talk on AI-driven discovery in medicine \u2014 as a personal highlight, noting how sharply the field has advanced in just one year, in step with the rapid progress of language models. Meetings of this scale, he added, are an invaluable chance to map the frontiers of bioinformatics, exchange ideas, and stay current with the trends shaping the discipline.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">For Szczerbiak, the conference was as much about listening as presenting. He singled out the keynote by Marinka Zitnik of Harvard Medical School \u2014 an \u201cextraordinary\u201d talk on AI-driven discovery in medicine \u2014 as a personal highlight, noting how sharply the field has advanced in just one year, in step with the rapid progress of language models. Meetings of this scale, he added, are an invaluable chance to map the frontiers of bioinformatics, exchange ideas, and stay current with the trends shaping the discipline.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-AyIYj1","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/columns","attrs":{"epStylingOptions":{"epCustomColumnsResponsiveEnabled":true,"epCustomColumnsReverseResponsiveEnabled":true,"epCustomColumnsSpacingResponsiveEnabled":true,"epCustomColumns":{"target":"wp-block-column","responsive":true,"hover":false,"options":[{"custom":true,"control":"ColumnToggle"},{"label":"Responsive 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class=\"wp-block-image size-large eplus-wrapper\"><img src=\"https:\/\/sano.science\/wp-content\/uploads\/2026\/07\/Pawel-Szczerbiak-Sanos-deepFRI2-at-ISMB-2026--768x1024.jpg\" alt=\"\" class=\"wp-image-32074\"\/><\/figure>\n","innerContent":["\n<figure class=\"wp-block-image size-large eplus-wrapper\"><img src=\"https:\/\/sano.science\/wp-content\/uploads\/2026\/07\/Pawel-Szczerbiak-Sanos-deepFRI2-at-ISMB-2026--768x1024.jpg\" alt=\"\" class=\"wp-image-32074\"\/><\/figure>\n"]}],"innerHTML":"\n<div class=\"wp-block-column eplus-wrapper\" style=\"flex-basis:33.33%\"><\/div>\n","innerContent":["\n<div class=\"wp-block-column eplus-wrapper\" style=\"flex-basis:33.33%\">",null,"<\/div>\n"]},{"blockName":"core\/column","attrs":{"width":"66.66%","epAnimationGeneratedClass":"edplus_anim-oYAaMK","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-hzijDX","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">The deepFRI2\u00a0project\u00a0was\u00a0also\u00a0the\u00a0subject\u00a0of a\u00a0recent\u00a0Sano\u00a0Seminar, \"Interpretable protein function predictions with deepFRI2,\" for anyone who would like to explore the\u00a0work\u00a0in\u00a0more\u00a0depth\u00a0(<a href=\"https:\/\/sano.science\/seminars\/interpretable-protein-function-predictions-with-deepfri2\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/interpretable-protein-function-predictions-with-deepfri2<\/a>).\u00a0<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">The deepFRI2\u00a0project\u00a0was\u00a0also\u00a0the\u00a0subject\u00a0of a\u00a0recent\u00a0Sano\u00a0Seminar, \"Interpretable protein function predictions with deepFRI2,\" for anyone who would like to explore the\u00a0work\u00a0in\u00a0more\u00a0depth\u00a0(<a href=\"https:\/\/sano.science\/seminars\/interpretable-protein-function-predictions-with-deepfri2\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/interpretable-protein-function-predictions-with-deepfri2<\/a>).\u00a0<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"10px","epAnimationGeneratedClass":"edplus_anim-MRklgG","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-sn9zRP","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">Sano's presence at ISMB 2026 underscores the institute's growing role in the international computational medicine community \u2014 and its commitment to developing AI tools that are not only powerful, but also transparent and trustworthy.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Sano's presence at ISMB 2026 underscores the institute's growing role in the international computational medicine community \u2014 and its commitment to developing AI tools that are not only powerful, but also transparent and trustworthy.<\/p>\n"]}],"innerHTML":"\n<div class=\"wp-block-column eplus-wrapper\" style=\"flex-basis:66.66%\">\n\n\n\n<\/div>\n","innerContent":["\n<div class=\"wp-block-column eplus-wrapper\" style=\"flex-basis:66.66%\">",null,"\n\n",null,"\n\n",null,"<\/div>\n"]}],"innerHTML":"<div class=\"wp-block-columns eplus-wrapper eplus-styles-uid-5d2aa0\">\n\n<\/div>","innerContent":["\n<div class=\"wp-block-columns 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