{"id":12648,"date":"2023-07-13T12:40:54","date_gmt":"2023-07-13T10:40:54","guid":{"rendered":"https:\/\/new.sano.science\/?post_type=research&#038;p=12648"},"modified":"2024-01-05T13:48:03","modified_gmt":"2024-01-05T12:48:03","slug":"improved-myocardial-blood-flow-estimation-with-residual-activity-correction-and-motion-correction-in-18-f-flurpiridaz-pet-myocardial-perfusion-imaging","status":"publish","type":"research","link":"https:\/\/sano.science\/research\/improved-myocardial-blood-flow-estimation-with-residual-activity-correction-and-motion-correction-in-18-f-flurpiridaz-pet-myocardial-perfusion-imaging\/","title":{"rendered":"Improved myocardial blood flow estimation with residual activity correction and motion correction in 18 F-flurpiridaz PET myocardial perfusion imaging\u00a0"},"content":{"rendered":"\n<h2 class=\"wp-block-heading eplus-wrapper\">Otaki, Yuka; Kriekinge, Serge D. Van; Wei, Chih-Chun; Kavanagh, Paul; Singh, Ananya; Parekh, Tejas; Carli, Marcelo Di; Maddahi, Jamshid; Sitek, Arkadiusz; Buckley, Christopher; Berman, Daniel S.; Slomka, Piotr J.<\/h2>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">We sought to evaluate the diagnostic performance for coronary artery disease (CAD) of myocardial blood flow (MBF) quantification with 18F-flurpiridaz PET using motion correction (MC) and residual activity correction (RAC).<\/p>\n\n\n\n<p class=\" eplus-wrapper\">In total, 231 patients undergoing same-day pharmacologic rest and stress 18F-flurpiridaz PET from Phase III Flurpiridaz trial (NCT01347710) were studied. Frame-by-frame MC was performed and RAC was accomplished by subtracting the rest residual counts from the dynamic stress polar maps. MBF and myocardial flow reserve (MFR) were derived with a two-compartment early kinetic model for the entire left ventricle (global), each coronary territory, and 17-segment. Global and minimal values of three territorial (minimal vessel) and segmental estimation (minimal segment) of stress MBF and MFR were evaluated in the prediction of CAD. MBF and MFR were evaluated with and without MC and RAC (1: no MC\/no RAC, 2: no MC\/RAC, 3: MC\/RAC).<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n\t\n    \n        \n\t\t\t<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00259-021-05643-2\" target=\"_blank\" rel= \"noopener noreferrer nofollow\" class=\"button primary \">\n\n\t\t\t\t<span>\n\t\t\t\t\tREAD HERE\n\t\t\t\t<\/span>\n\n\t\t\t<\/a>\n\n        \n    \n","protected":false},"excerpt":{"rendered":"<p>In: European Journal of Nuclear Medicine and Molecular Imaging, 2021.<\/p>\n","protected":false},"featured_media":0,"template":"","research_type":[8],"research_team":[17],"class_list":["post-12648","research","type-research","status-publish","hentry","research_type-publications","research_team-health-informatics-group-higs"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Improved myocardial blood flow estimation with residual activity correction and motion correction in 18 F-flurpiridaz PET myocardial perfusion imaging\u00a0 - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/research\/improved-myocardial-blood-flow-estimation-with-residual-activity-correction-and-motion-correction-in-18-f-flurpiridaz-pet-myocardial-perfusion-imaging\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Improved myocardial blood flow estimation with residual activity correction and motion correction in 18 F-flurpiridaz PET myocardial perfusion imaging\u00a0\" \/>\n<meta property=\"og:description\" content=\"In: European Journal of Nuclear Medicine and Molecular Imaging, 2021.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/research\/improved-myocardial-blood-flow-estimation-with-residual-activity-correction-and-motion-correction-in-18-f-flurpiridaz-pet-myocardial-perfusion-imaging\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-05T12:48:03+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/research\\\/improved-myocardial-blood-flow-estimation-with-residual-activity-correction-and-motion-correction-in-18-f-flurpiridaz-pet-myocardial-perfusion-imaging\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/research\\\/improved-myocardial-blood-flow-estimation-with-residual-activity-correction-and-motion-correction-in-18-f-flurpiridaz-pet-myocardial-perfusion-imaging\\\/\",\"name\":\"Improved myocardial blood flow estimation with residual activity correction and motion correction in 18 F-flurpiridaz PET myocardial perfusion imaging\u00a0 - 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Van; Wei, Chih-Chun; Kavanagh, Paul; Singh, Ananya; Parekh, Tejas; Carli, Marcelo Di; Maddahi, Jamshid; Sitek, Arkadiusz; Buckley, Christopher; Berman, Daniel S.; Slomka, Piotr J.<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\">Otaki, Yuka; Kriekinge, Serge D. Van; Wei, Chih-Chun; Kavanagh, Paul; Singh, Ananya; Parekh, Tejas; Carli, Marcelo Di; Maddahi, Jamshid; Sitek, Arkadiusz; Buckley, Christopher; Berman, Daniel S.; Slomka, Piotr J.<\/h2>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-E1UJO8","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-Io1QMj","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">We sought to evaluate the diagnostic performance for coronary artery disease (CAD) of myocardial blood flow (MBF) quantification with 18F-flurpiridaz PET using motion correction (MC) and residual activity correction (RAC).<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">We sought to evaluate the diagnostic performance for coronary artery disease (CAD) of myocardial blood flow (MBF) quantification with 18F-flurpiridaz PET using motion correction (MC) and residual activity correction (RAC).<\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-3eIEOl","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">In total, 231 patients undergoing same-day pharmacologic rest and stress 18F-flurpiridaz PET from Phase III Flurpiridaz trial (NCT01347710) were studied. Frame-by-frame MC was performed and RAC was accomplished by subtracting the rest residual counts from the dynamic stress polar maps. MBF and myocardial flow reserve (MFR) were derived with a two-compartment early kinetic model for the entire left ventricle (global), each coronary territory, and 17-segment. Global and minimal values of three territorial (minimal vessel) and segmental estimation (minimal segment) of stress MBF and MFR were evaluated in the prediction of CAD. MBF and MFR were evaluated with and without MC and RAC (1: no MC\/no RAC, 2: no MC\/RAC, 3: MC\/RAC).<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">In total, 231 patients undergoing same-day pharmacologic rest and stress 18F-flurpiridaz PET from Phase III Flurpiridaz trial (NCT01347710) were studied. Frame-by-frame MC was performed and RAC was accomplished by subtracting the rest residual counts from the dynamic stress polar maps. MBF and myocardial flow reserve (MFR) were derived with a two-compartment early kinetic model for the entire left ventricle (global), each coronary territory, and 17-segment. Global and minimal values of three territorial (minimal vessel) and segmental estimation (minimal segment) of stress MBF and MFR were evaluated in the prediction of CAD. MBF and MFR were evaluated with and without MC and RAC (1: no MC\/no RAC, 2: no MC\/RAC, 3: MC\/RAC).<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-9X7jUe","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"acf\/button","attrs":{"title":"READ HERE","button_type":"link","url":"https:\/\/link.springer.com\/article\/10.1007\/s00259-021-05643-2","button_style":"primary","target":"_blank","button_extra_classes":""},"innerBlocks":[],"innerHTML":"","innerContent":[]}],"meta_data":{"is_automatically_other_posts":true,"number_of_posts":"3","is_automatically_check_also_posts":true},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/12648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/research"}],"version-history":[{"count":4,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/12648\/revisions"}],"predecessor-version":[{"id":14707,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/12648\/revisions\/14707"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=12648"}],"wp:term":[{"taxonomy":"research_type","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_type?post=12648"},{"taxonomy":"research_team","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_team?post=12648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}