{"id":14789,"date":"2024-01-09T18:18:22","date_gmt":"2024-01-09T17:18:22","guid":{"rendered":"https:\/\/sano.science\/?post_type=research&#038;p=14789"},"modified":"2024-01-09T18:19:28","modified_gmt":"2024-01-09T17:19:28","slug":"dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins","status":"publish","type":"research","link":"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/","title":{"rendered":"Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins"},"content":{"rendered":"\n<h2 class=\"wp-block-heading eplus-wrapper\">Irena Roterman, Katarzyna Stapor, K<strong>rzysztof G\u0105dek, Tomasz Guba\u0142a , Piotr Nowakowski<\/strong>, Piotr Fabian and Leszek Konieczny<\/h2>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">The natural environment of proteins is the polar aquatic environment and the hydrophobic (amphipathic) environment of the membrane. The fuzzy oil drop model (FOD) used to characterize water-soluble proteins, as well as its modified version FOD-M, enables a mathematical description of the presence and influence of diverse environments on protein structure. The present work characterized the structures of membrane proteins, including those that act as channels, and a water-soluble protein for contrast. The purpose of the analysis was to verify the possibility that an external force field can be used in the simulation of the protein-folding process, taking into account the diverse nature of the environment that guarantees a structure showing biological activity.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n\t\n    \n        \n\t\t\t<a href=\"https:\/\/www.mdpi.com\/2077-0375\/12\/1\/50\/htm\" target=\"_blank\" rel= \"noopener noreferrer nofollow\" class=\"button primary \">\n\n\t\t\t\t<span>\n\t\t\t\t\tREAD HERE\n\t\t\t\t<\/span>\n\n\t\t\t<\/a>\n\n        \n    \n","protected":false},"excerpt":{"rendered":"<p>In: Membrane Biological Function in Health and Disease, 2021.<\/p>\n","protected":false},"featured_media":0,"template":"","research_type":[8],"research_team":[],"class_list":["post-14789","research","type-research","status-publish","hentry","research_type-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins\" \/>\n<meta property=\"og:description\" content=\"In: Membrane Biological Function in Health and Disease, 2021.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-09T17:19:28+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/research\\\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/research\\\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\\\/\",\"name\":\"Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins - Centre for Computational Personalized Medicine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#website\"},\"datePublished\":\"2024-01-09T17:18:22+00:00\",\"dateModified\":\"2024-01-09T17:19:28+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sano.science\\\/research\\\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sano.science\\\/research\\\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sano.science\\\/research\\\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sano.science\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\\\/\\\/sano.science\\\/research\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Publications\",\"item\":\"https:\\\/\\\/sano.science\\\/research-type\\\/publications\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sano.science\\\/#website\",\"url\":\"https:\\\/\\\/sano.science\\\/\",\"name\":\"Centre for Computational Personalized Medicine\",\"description\":\"Sano \u2013 Centre for Computational Medicine\",\"publisher\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sano.science\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/sano.science\\\/#organization\",\"name\":\"Sano \u2013 Centre for Computational Medicine\",\"alternateName\":\"Sano\",\"url\":\"https:\\\/\\\/sano.science\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sano.science\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/logo_sano_podstawowe.png\",\"contentUrl\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/logo_sano_podstawowe.png\",\"width\":700,\"height\":265,\"caption\":\"Sano \u2013 Centre for Computational Medicine\"},\"image\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/sano.science\\\/\",\"https:\\\/\\\/x.com\\\/sanoscience\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/sanoscience\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCDZ_8TcjMWUG2ZcgKKgfpwQ\",\"https:\\\/\\\/bsky.app\\\/profile\\\/sanoscience.bsky.social\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins - Centre for Computational Personalized Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/","og_locale":"en_US","og_type":"article","og_title":"Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins","og_description":"In: Membrane Biological Function in Health and Disease, 2021.","og_url":"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/","og_site_name":"Centre for Computational Personalized Medicine","article_publisher":"https:\/\/www.facebook.com\/sano.science\/","article_modified_time":"2024-01-09T17:19:28+00:00","twitter_card":"summary_large_image","twitter_site":"@sanoscience","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/","url":"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/","name":"Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins - Centre for Computational Personalized Medicine","isPartOf":{"@id":"https:\/\/sano.science\/#website"},"datePublished":"2024-01-09T17:18:22+00:00","dateModified":"2024-01-09T17:19:28+00:00","breadcrumb":{"@id":"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sano.science\/research\/dependence-of-protein-structure-on-environment-fod-model-applied-to-membrane-proteins\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sano.science\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/sano.science\/research\/"},{"@type":"ListItem","position":3,"name":"Publications","item":"https:\/\/sano.science\/research-type\/publications\/"},{"@type":"ListItem","position":4,"name":"Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins"}]},{"@type":"WebSite","@id":"https:\/\/sano.science\/#website","url":"https:\/\/sano.science\/","name":"Centre for Computational Personalized Medicine","description":"Sano \u2013 Centre for Computational Medicine","publisher":{"@id":"https:\/\/sano.science\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sano.science\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/sano.science\/#organization","name":"Sano \u2013 Centre for Computational Medicine","alternateName":"Sano","url":"https:\/\/sano.science\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sano.science\/#\/schema\/logo\/image\/","url":"https:\/\/sano.science\/wp-content\/uploads\/2024\/05\/logo_sano_podstawowe.png","contentUrl":"https:\/\/sano.science\/wp-content\/uploads\/2024\/05\/logo_sano_podstawowe.png","width":700,"height":265,"caption":"Sano \u2013 Centre for Computational Medicine"},"image":{"@id":"https:\/\/sano.science\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/sano.science\/","https:\/\/x.com\/sanoscience","https:\/\/www.linkedin.com\/company\/sanoscience\/","https:\/\/www.youtube.com\/channel\/UCDZ_8TcjMWUG2ZcgKKgfpwQ","https:\/\/bsky.app\/profile\/sanoscience.bsky.social"]}]}},"acf":[],"gutenberg_blocks":[{"blockName":"custom-styles","attrs":{"styles":""}},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-zKXsIA","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\">Irena Roterman, Katarzyna Stapor, K<strong>rzysztof G\u0105dek, Tomasz Guba\u0142a , Piotr Nowakowski<\/strong>, Piotr Fabian and Leszek Konieczny<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\">Irena Roterman, Katarzyna Stapor, K<strong>rzysztof G\u0105dek, Tomasz Guba\u0142a , Piotr Nowakowski<\/strong>, Piotr Fabian and Leszek Konieczny<\/h2>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-fKs3Fp","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-acUE6q","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">The natural environment of proteins is the polar aquatic environment and the hydrophobic (amphipathic) environment of the membrane. The fuzzy oil drop model (FOD) used to characterize water-soluble proteins, as well as its modified version FOD-M, enables a mathematical description of the presence and influence of diverse environments on protein structure. The present work characterized the structures of membrane proteins, including those that act as channels, and a water-soluble protein for contrast. The purpose of the analysis was to verify the possibility that an external force field can be used in the simulation of the protein-folding process, taking into account the diverse nature of the environment that guarantees a structure showing biological activity.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">The natural environment of proteins is the polar aquatic environment and the hydrophobic (amphipathic) environment of the membrane. The fuzzy oil drop model (FOD) used to characterize water-soluble proteins, as well as its modified version FOD-M, enables a mathematical description of the presence and influence of diverse environments on protein structure. The present work characterized the structures of membrane proteins, including those that act as channels, and a water-soluble protein for contrast. The purpose of the analysis was to verify the possibility that an external force field can be used in the simulation of the protein-folding process, taking into account the diverse nature of the environment that guarantees a structure showing biological activity.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-BByC5N","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"acf\/button","attrs":{"title":"READ HERE","button_type":"link","url":"https:\/\/www.mdpi.com\/2077-0375\/12\/1\/50\/htm","button_style":"primary","target":"_blank","button_extra_classes":""},"innerBlocks":[],"innerHTML":"","innerContent":[]}],"meta_data":{"is_automatically_other_posts":true,"number_of_posts":"3","is_automatically_check_also_posts":true},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/research"}],"version-history":[{"count":4,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14789\/revisions"}],"predecessor-version":[{"id":14793,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14789\/revisions\/14793"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=14789"}],"wp:term":[{"taxonomy":"research_type","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_type?post=14789"},{"taxonomy":"research_team","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_team?post=14789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}