{"id":14850,"date":"2024-01-10T20:45:03","date_gmt":"2024-01-10T19:45:03","guid":{"rendered":"https:\/\/sano.science\/?post_type=research&#038;p=14850"},"modified":"2024-01-10T20:45:03","modified_gmt":"2024-01-10T19:45:03","slug":"connexins-and-pannexins-similarities-and-differences-according-to-the-fod-m-model","status":"publish","type":"research","link":"https:\/\/sano.science\/research\/connexins-and-pannexins-similarities-and-differences-according-to-the-fod-m-model\/","title":{"rendered":"Connexins and Pannexins\u2014Similarities and Differences According to the FOD-M Model"},"content":{"rendered":"\n<h2 class=\"wp-block-heading eplus-wrapper\">I. Roterman, K. St\u0105por, P. Fabian, L. Konieczny<\/h2>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals. Their common role is to connect the external environment with the cytoplasm of the cell, while connexin is also able to link two cells together allowing the transport from one to another. The analysis presented here aims to identify the similarities and differences between connexin and pannexin. As a comparative criterion, the hydrophobicity distribution in the structure of the discussed proteins was used. The comparative analysis is carried out with the use of a mathematical model, the FOD-M model (fuzzy oil drop model in its Modified version) expressing the specificity of the membrane\u2019s external field, which in the case of the discussed proteins is significantly different from the external field for globular proteins in the polar environment of water. The characteristics of the external force field influence the structure of protein allowing the activity in a different environment.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>:\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=connexin\">connexin<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=pannexin\">pannexin<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=membrane+proteins\">membrane proteins<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=transmembrane+channel\">transmembrane channel<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=hydrophobicity\">hydrophobicity<\/a><\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n\t\n    \n        \n\t\t\t<a href=\"https:\/\/www.mdpi.com\/2227-9059\/10\/7\/1504\" target=\"_blank\" rel= \"noopener noreferrer nofollow\" class=\"button primary \">\n\n\t\t\t\t<span>\n\t\t\t\t\tREAD HERE\n\t\t\t\t<\/span>\n\n\t\t\t<\/a>\n\n        \n    \n","protected":false},"excerpt":{"rendered":"<p>In: Biomedicines, 2022.<\/p>\n","protected":false},"featured_media":0,"template":"","research_type":[8],"research_team":[],"class_list":["post-14850","research","type-research","status-publish","hentry","research_type-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - 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Roterman, K. St\u0105por, P. Fabian, L. Konieczny<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\">I. Roterman, K. St\u0105por, P. Fabian, L. Konieczny<\/h2>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-ChPWWm","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-PzHDAM","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals. Their common role is to connect the external environment with the cytoplasm of the cell, while connexin is also able to link two cells together allowing the transport from one to another. The analysis presented here aims to identify the similarities and differences between connexin and pannexin. As a comparative criterion, the hydrophobicity distribution in the structure of the discussed proteins was used. The comparative analysis is carried out with the use of a mathematical model, the FOD-M model (fuzzy oil drop model in its Modified version) expressing the specificity of the membrane\u2019s external field, which in the case of the discussed proteins is significantly different from the external field for globular proteins in the polar environment of water. The characteristics of the external force field influence the structure of protein allowing the activity in a different environment.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals. Their common role is to connect the external environment with the cytoplasm of the cell, while connexin is also able to link two cells together allowing the transport from one to another. The analysis presented here aims to identify the similarities and differences between connexin and pannexin. As a comparative criterion, the hydrophobicity distribution in the structure of the discussed proteins was used. The comparative analysis is carried out with the use of a mathematical model, the FOD-M model (fuzzy oil drop model in its Modified version) expressing the specificity of the membrane\u2019s external field, which in the case of the discussed proteins is significantly different from the external field for globular proteins in the polar environment of water. The characteristics of the external force field influence the structure of protein allowing the activity in a different environment.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"20px","epAnimationGeneratedClass":"edplus_anim-vIONZb","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-9nlCJw","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>:\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=connexin\">connexin<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=pannexin\">pannexin<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=membrane+proteins\">membrane proteins<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=transmembrane+channel\">transmembrane channel<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=hydrophobicity\">hydrophobicity<\/a><\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>:\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=connexin\">connexin<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=pannexin\">pannexin<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=membrane+proteins\">membrane proteins<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=transmembrane+channel\">transmembrane channel<\/a>;\u00a0<a href=\"https:\/\/www.mdpi.com\/search?q=hydrophobicity\">hydrophobicity<\/a><\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-ChPWWm","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"acf\/button","attrs":{"title":"READ HERE","button_type":"link","url":"https:\/\/www.mdpi.com\/2227-9059\/10\/7\/1504","button_style":"primary","target":"_blank","button_extra_classes":""},"innerBlocks":[],"innerHTML":"","innerContent":[]}],"meta_data":{"is_automatically_other_posts":true,"number_of_posts":"3","is_automatically_check_also_posts":true},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14850","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/research"}],"version-history":[{"count":2,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14850\/revisions"}],"predecessor-version":[{"id":14852,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14850\/revisions\/14852"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=14850"}],"wp:term":[{"taxonomy":"research_type","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_type?post=14850"},{"taxonomy":"research_team","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_team?post=14850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}