{"id":14877,"date":"2024-01-12T16:54:55","date_gmt":"2024-01-12T15:54:55","guid":{"rendered":"https:\/\/sano.science\/?post_type=research&#038;p=14877"},"modified":"2024-01-12T16:54:56","modified_gmt":"2024-01-12T15:54:56","slug":"a-stochastic-model-of-translocation-of-knotted-proteins","status":"publish","type":"research","link":"https:\/\/sano.science\/research\/a-stochastic-model-of-translocation-of-knotted-proteins\/","title":{"rendered":"A Stochastic Model of Translocation of Knotted Proteins"},"content":{"rendered":"\n<h2 class=\"wp-block-heading eplus-wrapper\">Karol Capa\u0142a, Piotr Szymczak<\/h2>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">Knotted proteins, when forced through the pores, can get stuck if the knots in their backbone tighten under force. Alternatively, the knot can slide off the chain, making translocation possible. We construct a simple energy landscape model of this process with a time-periodic potential that mimics the action of a molecular motor. We calculate the translocation time as a function of the period of the pulling force, discuss the asymptotic limits and biological relevance of the results.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n\t\n    \n        \n\t\t\t<a href=\"https:\/\/journals.aps.org\/pre\/abstract\/10.1103\/PhysRevE.106.054406\" target=\"_blank\" rel= \"noopener noreferrer nofollow\" class=\"button primary \">\n\n\t\t\t\t<span>\n\t\t\t\t\tREAD HERE\n\t\t\t\t<\/span>\n\n\t\t\t<\/a>\n\n        \n    \n","protected":false},"excerpt":{"rendered":"<p>In: Physical Review E, 2022.<\/p>\n","protected":false},"featured_media":0,"template":"","research_type":[8],"research_team":[14],"class_list":["post-14877","research","type-research","status-publish","hentry","research_type-publications","research_team-computational-intelligence"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>A Stochastic Model of Translocation of Knotted Proteins - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/research\/a-stochastic-model-of-translocation-of-knotted-proteins\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Stochastic Model of Translocation of Knotted Proteins\" \/>\n<meta property=\"og:description\" content=\"In: Physical Review E, 2022.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/research\/a-stochastic-model-of-translocation-of-knotted-proteins\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-12T15:54:56+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/research\\\/a-stochastic-model-of-translocation-of-knotted-proteins\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/research\\\/a-stochastic-model-of-translocation-of-knotted-proteins\\\/\",\"name\":\"A Stochastic Model of Translocation of Knotted Proteins - 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Alternatively, the knot can slide off the chain, making translocation possible. We construct a simple energy landscape model of this process with a time-periodic potential that mimics the action of a molecular motor. We calculate the translocation time as a function of the period of the pulling force, discuss the asymptotic limits and biological relevance of the results.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Knotted proteins, when forced through the pores, can get stuck if the knots in their backbone tighten under force. Alternatively, the knot can slide off the chain, making translocation possible. We construct a simple energy landscape model of this process with a time-periodic potential that mimics the action of a molecular motor. We calculate the translocation time as a function of the period of the pulling force, discuss the asymptotic limits and biological relevance of the results.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-GbY76f","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"acf\/button","attrs":{"title":"READ HERE","button_type":"link","url":"https:\/\/journals.aps.org\/pre\/abstract\/10.1103\/PhysRevE.106.054406","button_style":"primary","target":"_blank","button_extra_classes":""},"innerBlocks":[],"innerHTML":"","innerContent":[]}],"meta_data":{"is_automatically_other_posts":true,"number_of_posts":"3","is_automatically_check_also_posts":true},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/research"}],"version-history":[{"count":2,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14877\/revisions"}],"predecessor-version":[{"id":14879,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/14877\/revisions\/14879"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=14877"}],"wp:term":[{"taxonomy":"research_type","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_type?post=14877"},{"taxonomy":"research_team","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_team?post=14877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}