{"id":18615,"date":"2024-08-13T15:46:49","date_gmt":"2024-08-13T13:46:49","guid":{"rendered":"https:\/\/sano.science\/?post_type=research&#038;p=18615"},"modified":"2025-02-05T11:51:39","modified_gmt":"2025-02-05T10:51:39","slug":"local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation","status":"publish","type":"research","link":"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/","title":{"rendered":"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation"},"content":{"rendered":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-karolina-tlalka-harry-saxton-ian-halliday-xu-xu-daniel-taylor-andrew-narracott-maciej-malawski\">Karolina Tla\u0142ka, Harry Saxton, Ian Halliday, Xu Xu, Daniel Taylor, Andrew Narracott, Maciej Malawski<\/h2>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">In this study, the authors performed a local sensitivity analysis, a computationally inexpensive method of identifying influential parameters, supplemented with orthogonality analysis. A zero-dimensional closed-loop model with a one-chamber heart was analyzed in two versions &#8211; regulated in a rest state (with the representation of baroreflex proposed by Ursino in doi: 10.1152\/ajpheart.1998.275.5.H1733, but without any disturbance) and unregulated. Comparing results for the models, it is clear that the influence of baroreflex parameters is visibly smaller than cardiovascular (regulation set-point is the exception). Vagal activity dominates. The conclusion is that local sensitivity analysis may be successfully used to increase knowledge about the model and to validate it, but one must be aware of its limitations.<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\"><strong>Authors<\/strong>: Karolina Tla\u0142ka, Harry Saxton, Ian Halliday, Xu Xu, Daniel Taylor, Andrew Narracott, Maciej Malawski<\/p>\n\n\n\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: <a href=\"https:\/\/doi.org\/10.1007\/978-3-031-63772-8_17\">doi.org\/10.1007\/978-3-031-63772-8_17<\/a><\/p>\n\n\n\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: model development, sensitivity analysis, baroreflex<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n\t\n    \n        \n\t\t\t<a href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-031-63772-8_17\" target=\"_self\"  class=\"button primary \">\n\n\t\t\t\t<span>\n\t\t\t\t\tREAD HERE\n\t\t\t\t<\/span>\n\n\t\t\t<\/a>\n\n        \n    \n","protected":false},"excerpt":{"rendered":"<p>conference manuscript: Springer, 2024<\/p>\n","protected":false},"featured_media":0,"template":"","research_type":[8],"research_team":[16],"class_list":["post-18615","research","type-research","status-publish","hentry","research_type-publications","research_team-extreme-scale-data-and-computing"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation\" \/>\n<meta property=\"og:description\" content=\"conference manuscript: Springer, 2024\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-05T10:51:39+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/research\\\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/research\\\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\\\/\",\"name\":\"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation - Centre for Computational Personalized Medicine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#website\"},\"datePublished\":\"2024-08-13T13:46:49+00:00\",\"dateModified\":\"2025-02-05T10:51:39+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sano.science\\\/research\\\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sano.science\\\/research\\\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sano.science\\\/research\\\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sano.science\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\\\/\\\/sano.science\\\/research\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Publications\",\"item\":\"https:\\\/\\\/sano.science\\\/research-type\\\/publications\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sano.science\\\/#website\",\"url\":\"https:\\\/\\\/sano.science\\\/\",\"name\":\"Centre for Computational Personalized Medicine\",\"description\":\"Sano \u2013 Centre for Computational Medicine\",\"publisher\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sano.science\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/sano.science\\\/#organization\",\"name\":\"Sano \u2013 Centre for Computational Medicine\",\"alternateName\":\"Sano\",\"url\":\"https:\\\/\\\/sano.science\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sano.science\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/logo_sano_podstawowe.png\",\"contentUrl\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/logo_sano_podstawowe.png\",\"width\":700,\"height\":265,\"caption\":\"Sano \u2013 Centre for Computational Medicine\"},\"image\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/sano.science\\\/\",\"https:\\\/\\\/x.com\\\/sanoscience\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/sanoscience\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCDZ_8TcjMWUG2ZcgKKgfpwQ\",\"https:\\\/\\\/bsky.app\\\/profile\\\/sanoscience.bsky.social\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation - Centre for Computational Personalized Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/","og_locale":"en_US","og_type":"article","og_title":"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation","og_description":"conference manuscript: Springer, 2024","og_url":"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/","og_site_name":"Centre for Computational Personalized Medicine","article_publisher":"https:\/\/www.facebook.com\/sano.science\/","article_modified_time":"2025-02-05T10:51:39+00:00","twitter_card":"summary_large_image","twitter_site":"@sanoscience","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/","url":"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/","name":"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation - Centre for Computational Personalized Medicine","isPartOf":{"@id":"https:\/\/sano.science\/#website"},"datePublished":"2024-08-13T13:46:49+00:00","dateModified":"2025-02-05T10:51:39+00:00","breadcrumb":{"@id":"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sano.science\/research\/local-sensitivity-analysis-of-a-closed-loop-in-silico-model-of-the-human-baroregulation\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sano.science\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/sano.science\/research\/"},{"@type":"ListItem","position":3,"name":"Publications","item":"https:\/\/sano.science\/research-type\/publications\/"},{"@type":"ListItem","position":4,"name":"Local Sensitivity Analysis of\u00a0a\u00a0Closed-Loop\u00a0in Silico\u00a0Model of\u00a0the\u00a0Human Baroregulation"}]},{"@type":"WebSite","@id":"https:\/\/sano.science\/#website","url":"https:\/\/sano.science\/","name":"Centre for Computational Personalized Medicine","description":"Sano \u2013 Centre for Computational Medicine","publisher":{"@id":"https:\/\/sano.science\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sano.science\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/sano.science\/#organization","name":"Sano \u2013 Centre for Computational Medicine","alternateName":"Sano","url":"https:\/\/sano.science\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sano.science\/#\/schema\/logo\/image\/","url":"https:\/\/sano.science\/wp-content\/uploads\/2024\/05\/logo_sano_podstawowe.png","contentUrl":"https:\/\/sano.science\/wp-content\/uploads\/2024\/05\/logo_sano_podstawowe.png","width":700,"height":265,"caption":"Sano \u2013 Centre for Computational Medicine"},"image":{"@id":"https:\/\/sano.science\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/sano.science\/","https:\/\/x.com\/sanoscience","https:\/\/www.linkedin.com\/company\/sanoscience\/","https:\/\/www.youtube.com\/channel\/UCDZ_8TcjMWUG2ZcgKKgfpwQ","https:\/\/bsky.app\/profile\/sanoscience.bsky.social"]}]}},"acf":[],"gutenberg_blocks":[{"blockName":"custom-styles","attrs":{"styles":""}},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-dxa5g6","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-karolina-tlalka-harry-saxton-ian-halliday-xu-xu-daniel-taylor-andrew-narracott-maciej-malawski\">Karolina Tla\u0142ka, Harry Saxton, Ian Halliday, Xu Xu, Daniel Taylor, Andrew Narracott, Maciej Malawski<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-karolina-tlalka-harry-saxton-ian-halliday-xu-xu-daniel-taylor-andrew-narracott-maciej-malawski\">Karolina Tla\u0142ka, Harry Saxton, Ian Halliday, Xu Xu, Daniel Taylor, Andrew Narracott, Maciej Malawski<\/h2>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-iuxabp","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-N12jnw","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">In this study, the authors performed a local sensitivity analysis, a computationally inexpensive method of identifying influential parameters, supplemented with orthogonality analysis. A zero-dimensional closed-loop model with a one-chamber heart was analyzed in two versions - regulated in a rest state (with the representation of baroreflex proposed by Ursino in doi: 10.1152\/ajpheart.1998.275.5.H1733, but without any disturbance) and unregulated. Comparing results for the models, it is clear that the influence of baroreflex parameters is visibly smaller than cardiovascular (regulation set-point is the exception). Vagal activity dominates. The conclusion is that local sensitivity analysis may be successfully used to increase knowledge about the model and to validate it, but one must be aware of its limitations.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">In this study, the authors performed a local sensitivity analysis, a computationally inexpensive method of identifying influential parameters, supplemented with orthogonality analysis. A zero-dimensional closed-loop model with a one-chamber heart was analyzed in two versions - regulated in a rest state (with the representation of baroreflex proposed by Ursino in doi: 10.1152\/ajpheart.1998.275.5.H1733, but without any disturbance) and unregulated. Comparing results for the models, it is clear that the influence of baroreflex parameters is visibly smaller than cardiovascular (regulation set-point is the exception). Vagal activity dominates. The conclusion is that local sensitivity analysis may be successfully used to increase knowledge about the model and to validate it, but one must be aware of its limitations.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-iuxabp","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-s6PQB6","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><strong>Authors<\/strong>: Karolina Tla\u0142ka, Harry Saxton, Ian Halliday, Xu Xu, Daniel Taylor, Andrew Narracott, Maciej Malawski<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><strong>Authors<\/strong>: Karolina Tla\u0142ka, Harry Saxton, Ian Halliday, Xu Xu, Daniel Taylor, Andrew Narracott, Maciej Malawski<\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-aKuwMF","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: <a href=\"https:\/\/doi.org\/10.1007\/978-3-031-63772-8_17\">doi.org\/10.1007\/978-3-031-63772-8_17<\/a><\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: <a href=\"https:\/\/doi.org\/10.1007\/978-3-031-63772-8_17\">doi.org\/10.1007\/978-3-031-63772-8_17<\/a><\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-404zct","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: model development, sensitivity analysis, baroreflex<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: model development, sensitivity analysis, baroreflex<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-iuxabp","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"acf\/button","attrs":{"title":"READ HERE","button_type":"link","url":"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-031-63772-8_17","button_style":"primary","target":"_self","button_extra_classes":""},"innerBlocks":[],"innerHTML":"","innerContent":[]}],"meta_data":{"is_automatically_other_posts":true,"number_of_posts":"3","is_automatically_check_also_posts":true},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/18615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/research"}],"version-history":[{"count":15,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/18615\/revisions"}],"predecessor-version":[{"id":21145,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research\/18615\/revisions\/21145"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=18615"}],"wp:term":[{"taxonomy":"research_type","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_type?post=18615"},{"taxonomy":"research_team","embeddable":true,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/research_team?post=18615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}