{"id":23099,"date":"2025-04-16T11:09:42","date_gmt":"2025-04-16T09:09:42","guid":{"rendered":"https:\/\/sano.science\/?post_type=research&#038;p=23099"},"modified":"2025-05-08T11:23:08","modified_gmt":"2025-05-08T09:23:08","slug":"differential-involvement-of-neurotransmitter-pathways-in-ad-bvftd-and-mci-whole-brain-mri-analysis","status":"publish","type":"research","link":"https:\/\/sano.science\/research\/differential-involvement-of-neurotransmitter-pathways-in-ad-bvftd-and-mci-whole-brain-mri-analysis\/","title":{"rendered":"Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis"},"content":{"rendered":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-ricardo-felix-nbsp-morais-nbsp-jose-maria-sousa-nbsp-cemal-nbsp-koba-nbsp-leon-nbsp-andres-tiago-jesus-nbsp-ines-nbsp-baldeiras-nbsp-tiago-gil-nbsp-oliveira-nbsp-isabel-nbsp-santana\">Ricardo F\u00e9lix&nbsp;Morais,&nbsp;Jos\u00e9 Maria Sousa,&nbsp; Cemal&nbsp; Koba,&nbsp; Leon&nbsp; Andres, Tiago Jesus,  &nbsp;In\u00eas&nbsp; Baldeiras,&nbsp;Tiago Gil&nbsp; Oliveira,&nbsp; Isabel &nbsp;Santana<\/h2>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">&nbsp;In the publication <strong>Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis<\/strong>, the authors explore how neurodegenerative conditions such as Alzheimer\u2019s disease (AD), mild cognitive impairment (MCI), and behavioral variant frontotemporal dementia (bvFTD) affect neurotransmitter systems differently. As these disorders grow more prevalent, understanding their neurochemical underpinnings becomes increasingly important. While structural brain changes have been widely studied, the role of neurotransmitter pathways has received less attention.<\/p>\n\n\n\n<p class=\" eplus-wrapper\">This study analyzed MRI data from 214 participants (89 AD, 74 bvFTD, 51 MCI) using FreeSurfer segmentation and JuSpace neurotransmitter maps. Volumetric and correlation analyses identified disease-specific patterns: AD-related atrophy was linked to dopaminergic and GABAergic systems; bvFTD showed associations with mu-opioid receptor loss; MCI exhibited early serotonergic disruptions before structural changes were evident.<\/p>\n\n\n\n<p class=\" eplus-wrapper\">The findings reveal distinct neurochemical profiles for each condition, suggesting that neurotransmitter mapping may provide valuable insights for diagnosis and therapeutic strategies beyond conventional imaging approaches.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\"><strong><strong>Autors<\/strong>:<\/strong> Ricardo F\u00e9lix\u00a0Morais,\u00a0<a href=\"https:\/\/sano.science\/people\/jose-sousa\/\">Jos\u00e9 Maria Sousa<\/a>,\u00a0 <a href=\"https:\/\/sano.science\/people\/cemal-koba\/\">Cemal\u00a0 Koba<\/a>,\u00a0 Leon\u00a0 Andres, Tiago Jesus, In\u00eas\u00a0 Baldeiras,\u00a0Tiago Gil\u00a0 Oliveira,\u00a0 Isabel \u00a0Santana<\/p>\n\n\n\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: 10.1016\/j.nbd.2025.106897<\/p>\n\n\n\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: JuSpace, Brain volumetry, Receptor density, Neuroimaging analysis, Neurotransmitter mapping, Dementia biomarkers<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<div class=\"wp-block-buttons eplus-wrapper is-layout-flex wp-block-buttons-is-layout-flex\"><\/div>\n\n\n\n\t\n    \n        \n\t\t\t<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0969996125001135?via%3Dihub#ks0005\" target=\"_blank\" rel= \"noopener noreferrer nofollow\" class=\"button primary \">\n\n\t\t\t\t<span>\n\t\t\t\t\tREAD HERE\n\t\t\t\t<\/span>\n\n\t\t\t<\/a>\n\n        \n    \n","protected":false},"excerpt":{"rendered":"<p>Article in journal: Neurobiology of Disease,  2025<\/p>\n","protected":false},"featured_media":0,"template":"","research_type":[8],"research_team":[15],"class_list":["post-23099","research","type-research","status-publish","hentry","research_type-publications","research_team-computational-neuroscience"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - 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As these disorders grow more prevalent, understanding their neurochemical underpinnings becomes increasingly important. While structural brain changes have been widely studied, the role of neurotransmitter pathways has received less attention.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">&nbsp;In the publication <strong>Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis<\/strong>, the authors explore how neurodegenerative conditions such as Alzheimer\u2019s disease (AD), mild cognitive impairment (MCI), and behavioral variant frontotemporal dementia (bvFTD) affect neurotransmitter systems differently. As these disorders grow more prevalent, understanding their neurochemical underpinnings becomes increasingly important. While structural brain changes have been widely studied, the role of neurotransmitter pathways has received less attention.<\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-QjyljR","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">This study analyzed MRI data from 214 participants (89 AD, 74 bvFTD, 51 MCI) using FreeSurfer segmentation and JuSpace neurotransmitter maps. Volumetric and correlation analyses identified disease-specific patterns: AD-related atrophy was linked to dopaminergic and GABAergic systems; bvFTD showed associations with mu-opioid receptor loss; MCI exhibited early serotonergic disruptions before structural changes were evident.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">This study analyzed MRI data from 214 participants (89 AD, 74 bvFTD, 51 MCI) using FreeSurfer segmentation and JuSpace neurotransmitter maps. Volumetric and correlation analyses identified disease-specific patterns: AD-related atrophy was linked to dopaminergic and GABAergic systems; bvFTD showed associations with mu-opioid receptor loss; MCI exhibited early serotonergic disruptions before structural changes were evident.<\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-52WlCB","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">The findings reveal distinct neurochemical profiles for each condition, suggesting that neurotransmitter mapping may provide valuable insights for diagnosis and therapeutic strategies beyond conventional imaging approaches.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">The findings reveal distinct neurochemical profiles for each condition, suggesting that neurotransmitter mapping may provide valuable insights for diagnosis and therapeutic strategies beyond conventional imaging approaches.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-GVGpom","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-30HfSq","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><strong><strong>Autors<\/strong>:<\/strong> Ricardo F\u00e9lix\u00a0Morais,\u00a0<a href=\"https:\/\/sano.science\/people\/jose-sousa\/\">Jos\u00e9 Maria Sousa<\/a>,\u00a0 <a href=\"https:\/\/sano.science\/people\/cemal-koba\/\">Cemal\u00a0 Koba<\/a>,\u00a0 Leon\u00a0 Andres, Tiago Jesus, In\u00eas\u00a0 Baldeiras,\u00a0Tiago Gil\u00a0 Oliveira,\u00a0 Isabel \u00a0Santana<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><strong><strong>Autors<\/strong>:<\/strong> Ricardo F\u00e9lix\u00a0Morais,\u00a0<a href=\"https:\/\/sano.science\/people\/jose-sousa\/\">Jos\u00e9 Maria Sousa<\/a>,\u00a0 <a href=\"https:\/\/sano.science\/people\/cemal-koba\/\">Cemal\u00a0 Koba<\/a>,\u00a0 Leon\u00a0 Andres, Tiago Jesus, In\u00eas\u00a0 Baldeiras,\u00a0Tiago Gil\u00a0 Oliveira,\u00a0 Isabel \u00a0Santana<\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-30HfSq","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: 10.1016\/j.nbd.2025.106897<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><strong>DOI<\/strong>: 10.1016\/j.nbd.2025.106897<\/p>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-u0oM2M","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: JuSpace, Brain volumetry, Receptor density, Neuroimaging analysis, Neurotransmitter mapping, Dementia biomarkers<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><strong>Keywords<\/strong>: JuSpace, Brain volumetry, Receptor density, Neuroimaging analysis, Neurotransmitter mapping, Dementia biomarkers<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"50px","epAnimationGeneratedClass":"edplus_anim-GVGpom","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer 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