{"id":19318,"date":"2024-10-15T09:41:10","date_gmt":"2024-10-15T07:41:10","guid":{"rendered":"https:\/\/sano.science\/?post_type=seminars&#038;p=19318"},"modified":"2024-10-15T10:59:56","modified_gmt":"2024-10-15T08:59:56","slug":"reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke","status":"publish","type":"seminars","link":"https:\/\/sano.science\/seminars\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\/","title":{"rendered":"144. Reshaped functional connectivity gradients in acute ischemic stroke"},"content":{"rendered":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-abstract\">Abstract:<\/h2>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">Ischemic brain stroke disrupts blood flow, leading to functional and structural changes associated with behavioral deficits. Importantly, despite this disruption occurring in localized regions, the resulting changes in the functional organization are both high-dimensional and widespread across the human cortex. However, the mechanisms with which these global patterns emerge and the subsequent behavioral deficits they entail, remain largely unexplored. Functional connectivity gradients provide consistent, reproducible, and robust low-dimensional representations of brain function that can be explored to reduce brain heterogeneity to a handful of axes along which brain function is organized. Here, we investigated how stroke disrupts this canonical gradient space by aligning each patient to a control-averaged gradient embedding and computing the distances to the \u201ccorrect\u201d positions to quantify functional deviations and their contribution to behavioral deficits. Importantly, we explicitly corrected these gradients for stroke-induced hemodynamic lags to further study their contribution. We found that lag correction enhanced the functional connectivity gradients most prominently in the second gradient, on which visual and somatomotor function is concentrated. Additionally, we identified significant functional deviations primarily within somatomotor, visual, and ventral attention networks, correlating with behavioral impairments. We studied the hemispheric asymmetries of these deviations finding that intact hemispheres preserve comparable patterns of asymmetry while damaged ones presented important changes. Lastly, right-sided lesions displayed more localized functional deviations than their contralateral lesions. Overall, we provide evidence that 1) correcting for hemodynamic lags improves gradient accuracy, as indicated by increased percentages of explained variance, and 2) behavioral impairments and hemispheric asymmetries result from a repositioning of region-based connectivity profiles in a low-dimensional, interpretable space. This suggests that large-scale brain function alterations manifest in slight, predictable movements largely confined to the visual-somatomotor axis.<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-about-the-author\">About the author:<\/h2>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">Cemal completed his PhD in computational neuroscience at IMT Lucca, Italy. For his thesis, he examined structural brain plasticity in the case of early and acquired blindness. He is interested in methods for processing and analysing neuroimaging data. He works on brain connectivity differences due to ischemic stroke and blindness.<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large eplus-wrapper\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"536\" src=\"https:\/\/sano.science\/wp-content\/uploads\/2024\/10\/Seminarium_Cemal-1024x536.png\" alt=\"\" class=\"wp-image-19331\" srcset=\"https:\/\/sano.science\/wp-content\/uploads\/2024\/10\/Seminarium_Cemal-1024x536.png 1024w, https:\/\/sano.science\/wp-content\/uploads\/2024\/10\/Seminarium_Cemal-300x157.png 300w, https:\/\/sano.science\/wp-content\/uploads\/2024\/10\/Seminarium_Cemal-768x402.png 768w, https:\/\/sano.science\/wp-content\/uploads\/2024\/10\/Seminarium_Cemal.png 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Cemal Koba &#8211; PostDoc in Computer Vision, Sano Centre for Computational Medicine, Krakow, Poland<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-19318","seminars","type-seminars","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Reshaped functional connectivity gradients in acute ischemic stroke<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/seminars\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"144. Reshaped functional connectivity gradients in acute ischemic stroke\" \/>\n<meta property=\"og:description\" content=\"Cemal Koba - PostDoc in Computer Vision, Sano Centre for Computational Medicine, Krakow, Poland\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sano.science\/seminars\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Computational Personalized Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/sano.science\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-15T08:59:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sano.science\/wp-content\/uploads\/2024\/10\/Seminarium_Cemal.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"628\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sanoscience\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sano.science\\\/seminars\\\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\\\/\",\"url\":\"https:\\\/\\\/sano.science\\\/seminars\\\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\\\/\",\"name\":\"Reshaped functional connectivity gradients in acute ischemic stroke\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sano.science\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sano.science\\\/seminars\\\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sano.science\\\/seminars\\\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/Seminarium_Cemal-1024x536.png\",\"datePublished\":\"2024-10-15T07:41:10+00:00\",\"dateModified\":\"2024-10-15T08:59:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sano.science\\\/seminars\\\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sano.science\\\/seminars\\\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sano.science\\\/seminars\\\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\\\/#primaryimage\",\"url\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/Seminarium_Cemal.png\",\"contentUrl\":\"https:\\\/\\\/sano.science\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/Seminarium_Cemal.png\",\"width\":1200,\"height\":628},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sano.science\\\/seminars\\\/reshaped-functional-connectivity-gradients-in-acute-ischemic-stroke\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sano.science\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Seminars\",\"item\":\"https:\\\/\\\/sano.science\\\/seminars\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"144. 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Reshaped functional connectivity gradients in acute ischemic stroke"}]},{"@type":"WebSite","@id":"https:\/\/sano.science\/#website","url":"https:\/\/sano.science\/","name":"Centre for Computational Personalized Medicine","description":"Sano \u2013 Centre for Computational Medicine","publisher":{"@id":"https:\/\/sano.science\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sano.science\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/sano.science\/#organization","name":"Sano \u2013 Centre for Computational Medicine","alternateName":"Sano","url":"https:\/\/sano.science\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sano.science\/#\/schema\/logo\/image\/","url":"https:\/\/sano.science\/wp-content\/uploads\/2024\/05\/logo_sano_podstawowe.png","contentUrl":"https:\/\/sano.science\/wp-content\/uploads\/2024\/05\/logo_sano_podstawowe.png","width":700,"height":265,"caption":"Sano \u2013 Centre for Computational Medicine"},"image":{"@id":"https:\/\/sano.science\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/sano.science\/","https:\/\/x.com\/sanoscience","https:\/\/www.linkedin.com\/company\/sanoscience\/","https:\/\/www.youtube.com\/channel\/UCDZ_8TcjMWUG2ZcgKKgfpwQ","https:\/\/bsky.app\/profile\/sanoscience.bsky.social"]}]}},"acf":[],"gutenberg_blocks":[{"blockName":"custom-styles","attrs":{"styles":""}},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-QPfsqH","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-abstract\">Abstract:<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-abstract\">Abstract:<\/h2>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-OyxP5i","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-2JdEgX","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">Ischemic brain stroke disrupts blood flow, leading to functional and structural changes associated with behavioral deficits. Importantly, despite this disruption occurring in localized regions, the resulting changes in the functional organization are both high-dimensional and widespread across the human cortex. However, the mechanisms with which these global patterns emerge and the subsequent behavioral deficits they entail, remain largely unexplored. Functional connectivity gradients provide consistent, reproducible, and robust low-dimensional representations of brain function that can be explored to reduce brain heterogeneity to a handful of axes along which brain function is organized. Here, we investigated how stroke disrupts this canonical gradient space by aligning each patient to a control-averaged gradient embedding and computing the distances to the \u201ccorrect\u201d positions to quantify functional deviations and their contribution to behavioral deficits. Importantly, we explicitly corrected these gradients for stroke-induced hemodynamic lags to further study their contribution. We found that lag correction enhanced the functional connectivity gradients most prominently in the second gradient, on which visual and somatomotor function is concentrated. Additionally, we identified significant functional deviations primarily within somatomotor, visual, and ventral attention networks, correlating with behavioral impairments. We studied the hemispheric asymmetries of these deviations finding that intact hemispheres preserve comparable patterns of asymmetry while damaged ones presented important changes. Lastly, right-sided lesions displayed more localized functional deviations than their contralateral lesions. Overall, we provide evidence that 1) correcting for hemodynamic lags improves gradient accuracy, as indicated by increased percentages of explained variance, and 2) behavioral impairments and hemispheric asymmetries result from a repositioning of region-based connectivity profiles in a low-dimensional, interpretable space. This suggests that large-scale brain function alterations manifest in slight, predictable movements largely confined to the visual-somatomotor axis.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Ischemic brain stroke disrupts blood flow, leading to functional and structural changes associated with behavioral deficits. Importantly, despite this disruption occurring in localized regions, the resulting changes in the functional organization are both high-dimensional and widespread across the human cortex. However, the mechanisms with which these global patterns emerge and the subsequent behavioral deficits they entail, remain largely unexplored. Functional connectivity gradients provide consistent, reproducible, and robust low-dimensional representations of brain function that can be explored to reduce brain heterogeneity to a handful of axes along which brain function is organized. Here, we investigated how stroke disrupts this canonical gradient space by aligning each patient to a control-averaged gradient embedding and computing the distances to the \u201ccorrect\u201d positions to quantify functional deviations and their contribution to behavioral deficits. Importantly, we explicitly corrected these gradients for stroke-induced hemodynamic lags to further study their contribution. We found that lag correction enhanced the functional connectivity gradients most prominently in the second gradient, on which visual and somatomotor function is concentrated. Additionally, we identified significant functional deviations primarily within somatomotor, visual, and ventral attention networks, correlating with behavioral impairments. We studied the hemispheric asymmetries of these deviations finding that intact hemispheres preserve comparable patterns of asymmetry while damaged ones presented important changes. Lastly, right-sided lesions displayed more localized functional deviations than their contralateral lesions. Overall, we provide evidence that 1) correcting for hemodynamic lags improves gradient accuracy, as indicated by increased percentages of explained variance, and 2) behavioral impairments and hemispheric asymmetries result from a repositioning of region-based connectivity profiles in a low-dimensional, interpretable space. This suggests that large-scale brain function alterations manifest in slight, predictable movements largely confined to the visual-somatomotor axis.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-OyxP5i","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-qLd8dj","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-about-the-author\">About the author:<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-about-the-author\">About the author:<\/h2>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-OyxP5i","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-PeBhGw","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\">Cemal completed his PhD in computational neuroscience at IMT Lucca, Italy. For his thesis, he examined structural brain plasticity in the case of early and acquired blindness. He is interested in methods for processing and analysing neuroimaging data. He works on brain connectivity differences due to ischemic stroke and blindness.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\">Cemal completed his PhD in computational neuroscience at IMT Lucca, Italy. For his thesis, he examined structural brain plasticity in the case of early and acquired blindness. He is interested in methods for processing and analysing neuroimaging data. He works on brain connectivity differences due to ischemic stroke and blindness.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-OyxP5i","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/image","attrs":{"id":19331,"sizeSlug":"large","linkDestination":"none","epAnimationGeneratedClass":"edplus_anim-Polxpw","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<figure class=\"wp-block-image size-large eplus-wrapper\"><img src=\"https:\/\/sano.science\/wp-content\/uploads\/2024\/10\/Seminarium_Cemal-1024x536.png\" alt=\"\" class=\"wp-image-19331\"\/><\/figure>\n","innerContent":["\n<figure class=\"wp-block-image size-large eplus-wrapper\"><img src=\"https:\/\/sano.science\/wp-content\/uploads\/2024\/10\/Seminarium_Cemal-1024x536.png\" alt=\"\" class=\"wp-image-19331\"\/><\/figure>\n"]}],"meta_data":{"event_day":"2024-10-21","event_time":"14.00 CEST","event_guest":"","has_medias":true,"medias":[{"icon":{"ID":1144,"id":1144,"title":"clock","filename":"clock.svg","filesize":1479,"url":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/clock.svg","link":"https:\/\/sano.science\/seminars\/79-digital-behaviour-change-interventions-dbci-from-design-to-implementation\/clock\/","alt":"clock Sano Seminar","author":"7","description":"","caption":"Sano Seminar clock","name":"clock","status":"inherit","uploaded_to":13471,"date":"2023-06-01 13:24:42","modified":"2024-10-09 16:41:04","menu_order":0,"mime_type":"image\/svg+xml","type":"image","subtype":"svg+xml","icon":"https:\/\/sano.science\/wp-includes\/images\/media\/default.png","width":56,"height":57,"sizes":{"thumbnail":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/clock.svg","thumbnail-width":147,"thumbnail-height":150,"medium":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/clock.svg","medium-width":294,"medium-height":300,"medium_large":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/clock.svg","medium_large-width":768,"medium_large-height":783,"large":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/clock.svg","large-width":1004,"large-height":1024,"1536x1536":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/clock.svg","1536x1536-width":56,"1536x1536-height":57,"2048x2048":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/clock.svg","2048x2048-width":56,"2048x2048-height":57}},"title":"21st October 2024,  14.00 CEST","link":""},{"icon":{"ID":1146,"id":1146,"title":"camera","filename":"camera.svg","filesize":1129,"url":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/camera.svg","link":"https:\/\/sano.science\/seminars\/79-digital-behaviour-change-interventions-dbci-from-design-to-implementation\/camera\/","alt":"camera Sano Seminar","author":"7","description":"","caption":"Sano Seminar camera","name":"camera","status":"inherit","uploaded_to":13471,"date":"2023-06-01 13:25:24","modified":"2024-10-09 16:42:29","menu_order":0,"mime_type":"image\/svg+xml","type":"image","subtype":"svg+xml","icon":"https:\/\/sano.science\/wp-includes\/images\/media\/default.png","width":60,"height":38,"sizes":{"thumbnail":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/camera.svg","thumbnail-width":150,"thumbnail-height":95,"medium":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/camera.svg","medium-width":300,"medium-height":190,"medium_large":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/camera.svg","medium_large-width":768,"medium_large-height":486,"large":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/camera.svg","large-width":1024,"large-height":648,"1536x1536":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/camera.svg","1536x1536-width":60,"1536x1536-height":38,"2048x2048":"https:\/\/sano.science\/wp-content\/uploads\/2023\/06\/camera.svg","2048x2048-width":60,"2048x2048-height":38}},"title":"Join via ZOOM on","link":{"title":"seminar.sano.science","url":"https:\/\/us06web.zoom.us\/j\/81263292238#success","target":"_blank"}}]},"_links":{"self":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/seminars\/19318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/seminars"}],"about":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/types\/seminars"}],"version-history":[{"count":6,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/seminars\/19318\/revisions"}],"predecessor-version":[{"id":19333,"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/seminars\/19318\/revisions\/19333"}],"wp:attachment":[{"href":"https:\/\/sano.science\/index.php\/wp-json\/wp\/v2\/media?parent=19318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}