{"id":23345,"date":"2025-04-30T14:18:16","date_gmt":"2025-04-30T12:18:16","guid":{"rendered":"https:\/\/sano.science\/?post_type=seminars&#038;p=23345"},"modified":"2025-05-06T11:21:12","modified_gmt":"2025-05-06T09:21:12","slug":"162-digital-twins-in-stroke-medicine-a-clinical-perspective","status":"publish","type":"seminars","link":"https:\/\/sano.science\/seminars\/162-digital-twins-in-stroke-medicine-a-clinical-perspective\/","title":{"rendered":"162. Digital Twins in Stroke Medicine: A Clinical Perspective"},"content":{"rendered":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-abstract\">Abstract:<\/h2>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\">This lecture will give:<\/p>\n\n\n<ul class=\"wp-block-list eplus-wrapper eplus-styles-uid-c43a8b\">\n<li class=\" eplus-wrapper\">Explain how Digital Twin Tools to be developed in GEMINI could facilitate decision making<\/li>\n\n\n\n<li class=\" eplus-wrapper\">An overview of the current status of reperfusion therapies in acute ischemic stroke<\/li>\n\n\n\n<li class=\" eplus-wrapper\">Provide insight into treatment decisions the physicians have to make in the acute setting to achieve fast and complete reperfusion<\/li>\n<\/ul>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-about-the-author\">About the author:<\/h2>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\"><strong>Prof. Dr. Charles Majoie, MD, PhD <\/strong>(m)<strong>, <\/strong>Professor of neuroradiology , interventional neuroradiologist at the department of Radiology and Nuclear Medicine in the Amsterdam UMC, location AMC, Amsterdam, The Netherlands.Heis as a research leader and co-research leader involved in multiple national and international research collaborations in the field of diagnosis and treatment of acute stroke. He was co-research leader of the ground breaking MRCLEAN trial, that demonstrated a clear improvement in clinical outcome of patients with acute ischemic stroke after endovascular treatment. This changed the practice how patients with severe strokes are now treated worldwide. He was co research leader of the MRCLEAN-2 trials&nbsp; (MRCLEAN NOIV, MED and LATE) within the CONTRAST collaboration aiming at treating more patients even more effectively. He was PI of the H2020 EU funded project INSIST, an international research consortium in the field of computational biomedicine, aiming at performing stroke trials in silico models reducing the number of animal experiments and refining human RCTs and is Co-PI of Horizon-Health 2023 EU funded project GEMINI, aiming at generating Digital Twins for Ischemic and Hemorrhagic stroke in order to improve personalized treatment. He is Co-PI of IRIS collaboration, an individual participant meta-analysis study-group of 6 RCTs investigating the value of IV thrombolysis before EVT in patients admitted directly to an intervention center. He was Chairman of the Dutch Society of Neuroradiology from 2012-2018. He has (co)authored more than 650 peer-reviewed manuscripts.<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<p class=\" eplus-wrapper\"><a href=\"https:\/\/www.amsterdamumc.org\/en\/research\/researchers\/charles-majoie.htm\">https:\/\/www.amsterdamumc.org\/en\/research\/researchers\/charles-majoie.htm<\/a>&nbsp;<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large eplus-wrapper\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"536\" src=\"https:\/\/sano.science\/wp-content\/uploads\/2025\/04\/Sano_Seminars_Majoie-1024x536.webp\" alt=\"\" class=\"wp-image-23378\" srcset=\"https:\/\/sano.science\/wp-content\/uploads\/2025\/04\/Sano_Seminars_Majoie-1024x536.webp 1024w, https:\/\/sano.science\/wp-content\/uploads\/2025\/04\/Sano_Seminars_Majoie-300x157.webp 300w, https:\/\/sano.science\/wp-content\/uploads\/2025\/04\/Sano_Seminars_Majoie-768x402.webp 768w, https:\/\/sano.science\/wp-content\/uploads\/2025\/04\/Sano_Seminars_Majoie.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Charles (C.B.L.M.) Majoie, Amsterdam University Medical Center, NL<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-23345","seminars","type-seminars","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>162. Digital Twins in Stroke Medicine: A Clinical Perspective - Centre for Computational Personalized Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sano.science\/seminars\/162-digital-twins-in-stroke-medicine-a-clinical-perspective\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"162. 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reperfusion<\/li>\n","innerContent":["\n<li class=\" eplus-wrapper\">Provide insight into treatment decisions the physicians have to make in the acute setting to achieve fast and complete reperfusion<\/li>\n"]}],"innerHTML":"<ul class=\"wp-block-list eplus-wrapper eplus-styles-uid-c43a8b\">\n\n\n\n<\/ul>","innerContent":["\n<ul class=\"wp-block-list eplus-wrapper\">",null,"\n\n",null,"\n\n",null,"<\/ul>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-FhSFgs","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/heading","attrs":{"epAnimationGeneratedClass":"edplus_anim-BLOnwz","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-about-the-author\">About the author:<\/h2>\n","innerContent":["\n<h2 class=\"wp-block-heading eplus-wrapper\" id=\"h-about-the-author\">About the author:<\/h2>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-FhSFgs","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-fT7nm3","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><strong>Prof. Dr. Charles Majoie, MD, PhD <\/strong>(m)<strong>, <\/strong>Professor of neuroradiology , interventional neuroradiologist at the department of Radiology and Nuclear Medicine in the Amsterdam UMC, location AMC, Amsterdam, The Netherlands.Heis as a research leader and co-research leader involved in multiple national and international research collaborations in the field of diagnosis and treatment of acute stroke. He was co-research leader of the ground breaking MRCLEAN trial, that demonstrated a clear improvement in clinical outcome of patients with acute ischemic stroke after endovascular treatment. This changed the practice how patients with severe strokes are now treated worldwide. He was co research leader of the MRCLEAN-2 trials&nbsp; (MRCLEAN NOIV, MED and LATE) within the CONTRAST collaboration aiming at treating more patients even more effectively. He was PI of the H2020 EU funded project INSIST, an international research consortium in the field of computational biomedicine, aiming at performing stroke trials in silico models reducing the number of animal experiments and refining human RCTs and is Co-PI of Horizon-Health 2023 EU funded project GEMINI, aiming at generating Digital Twins for Ischemic and Hemorrhagic stroke in order to improve personalized treatment. He is Co-PI of IRIS collaboration, an individual participant meta-analysis study-group of 6 RCTs investigating the value of IV thrombolysis before EVT in patients admitted directly to an intervention center. He was Chairman of the Dutch Society of Neuroradiology from 2012-2018. He has (co)authored more than 650 peer-reviewed manuscripts.<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><strong>Prof. Dr. Charles Majoie, MD, PhD <\/strong>(m)<strong>, <\/strong>Professor of neuroradiology , interventional neuroradiologist at the department of Radiology and Nuclear Medicine in the Amsterdam UMC, location AMC, Amsterdam, The Netherlands.Heis as a research leader and co-research leader involved in multiple national and international research collaborations in the field of diagnosis and treatment of acute stroke. He was co-research leader of the ground breaking MRCLEAN trial, that demonstrated a clear improvement in clinical outcome of patients with acute ischemic stroke after endovascular treatment. This changed the practice how patients with severe strokes are now treated worldwide. He was co research leader of the MRCLEAN-2 trials&nbsp; (MRCLEAN NOIV, MED and LATE) within the CONTRAST collaboration aiming at treating more patients even more effectively. He was PI of the H2020 EU funded project INSIST, an international research consortium in the field of computational biomedicine, aiming at performing stroke trials in silico models reducing the number of animal experiments and refining human RCTs and is Co-PI of Horizon-Health 2023 EU funded project GEMINI, aiming at generating Digital Twins for Ischemic and Hemorrhagic stroke in order to improve personalized treatment. He is Co-PI of IRIS collaboration, an individual participant meta-analysis study-group of 6 RCTs investigating the value of IV thrombolysis before EVT in patients admitted directly to an intervention center. He was Chairman of the Dutch Society of Neuroradiology from 2012-2018. He has (co)authored more than 650 peer-reviewed manuscripts.<\/p>\n"]},{"blockName":"core\/spacer","attrs":{"height":"30px","epAnimationGeneratedClass":"edplus_anim-FhSFgs","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n","innerContent":["\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer eplus-wrapper\"><\/div>\n"]},{"blockName":"core\/paragraph","attrs":{"epAnimationGeneratedClass":"edplus_anim-eUYcHv","epGeneratedClass":"eplus-wrapper"},"innerBlocks":[],"innerHTML":"\n<p class=\" eplus-wrapper\"><a href=\"https:\/\/www.amsterdamumc.org\/en\/research\/researchers\/charles-majoie.htm\">https:\/\/www.amsterdamumc.org\/en\/research\/researchers\/charles-majoie.htm<\/a>&nbsp;<\/p>\n","innerContent":["\n<p class=\" eplus-wrapper\"><a 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