162. Digital Twins in Stroke Medicine: A Clinical Perspective

Charles (C.B.L.M.) Majoie, Amsterdam University Medical Center, NL

Abstract:

This lecture will give:

  • Explain how Digital Twin Tools to be developed in GEMINI could facilitate decision making
  • An overview of the current status of reperfusion therapies in acute ischemic stroke
  • Provide insight into treatment decisions the physicians have to make in the acute setting to achieve fast and complete reperfusion

About the author:

Prof. Dr. Charles Majoie, MD, PhD (m), Professor of neuroradiology , interventional neuroradiologist at the department of Radiology and Nuclear Medicine in the Amsterdam UMC, location AMC, Amsterdam, The Netherlands.Heis as a research leader and co-research leader involved in multiple national and international research collaborations in the field of diagnosis and treatment of acute stroke. He was co-research leader of the ground breaking MRCLEAN trial, that demonstrated a clear improvement in clinical outcome of patients with acute ischemic stroke after endovascular treatment. This changed the practice how patients with severe strokes are now treated worldwide. He was co research leader of the MRCLEAN-2 trials  (MRCLEAN NOIV, MED and LATE) within the CONTRAST collaboration aiming at treating more patients even more effectively. He was PI of the H2020 EU funded project INSIST, an international research consortium in the field of computational biomedicine, aiming at performing stroke trials in silico models reducing the number of animal experiments and refining human RCTs and is Co-PI of Horizon-Health 2023 EU funded project GEMINI, aiming at generating Digital Twins for Ischemic and Hemorrhagic stroke in order to improve personalized treatment. He is Co-PI of IRIS collaboration, an individual participant meta-analysis study-group of 6 RCTs investigating the value of IV thrombolysis before EVT in patients admitted directly to an intervention center. He was Chairman of the Dutch Society of Neuroradiology from 2012-2018. He has (co)authored more than 650 peer-reviewed manuscripts.

https://www.amsterdamumc.org/en/research/researchers/charles-majoie.htm