165. From Aneurysm Wall to Decision Support: Insights from the AneuX Biobank

Abstract:

Intracranial aneurysm, a local outpouching of cerebral arteries, is present in 3 to 5% of the population. Once formed, an intracranial aneurysm can remain stable, grow or rupture. Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage and affects mostly young people with heavy consequences in terms of death, disabilities and socioeconomic burden. The objective of our work is to better understand the pathophysiology of intracranial aneurysms to reduce the burden of the disease on society. To this aim, we compare clinical data (initial and follow up observations and imaging) of patients recruited within the Geneva University Hospitals (cohort @neurIST) and in several international hospitals (cohort ISGC), and we analyze on intracranial aneurysms histological sections the presence of markers characteristics of intracranial aneurysm wall integrity and stability (AneuX biobank). We also investigate the evolution of this pathology using rat models. By working with different institutions, we combine multidisciplinary approaches to determine the causes, evolutions and treatments of intracranial aneurysms to improve their management. This presentation will focus on our research carry out thanks to our biobank and how our data contribute to the GEMINI project (A Generation of Multi-scale Digital Twins of Ischaemic and Haemorrhagic Stroke Patients).

About the author:

Sandrine Morel develops studies in fundamental sciences and carries out translational and clinical research. She masters these different types of research thanks to more than twenty years of experience in fundamental research and seven years in the clinical field. Sandrine Morel teaches at the Faculty of Medicine of the University of Geneva, is co-responsible for a module for PhD students and supervises master’s and doctoral students. Since 2015, Sandrine Morel is involved in national and international projects on intracranial aneurysms. More information on: https://orcid.org/0000-0003-1538-3553.

https://www.hug.ch/en/neurocentre