Krakow Conference on Computational Medicine 2025

Krakow Conference on Computational Medicine 2025

Enhancing Virtual Human Twin with AI solutions

October 15–17, 2025, Krakow

Two films about the Krakow Conference on Computational Medicine

Realisation: Jacek Przybylski

Filming, sound, editing: Marian Przybylski

Support: Marian Bubak and Maria Sendecka – Sano

Production: ACC Cyfronet AGH

Proceedings KCCM 2025

Organisers

Scope and topics

The conference’s motto is “Enhancing Virtual Human Twin with AI solutions“. Personalized medicine, focusing on the development of in-silico methods replacing in-vivo and in-vitro methods, should more effectively use the solutions brought by the AI ​​revolution based on machine learning and data analysis methods; perceived not as competitive, but as supporting existing modeling and simulation methods.

Given the Organisers’ expertise in both computer simulation and artificial intelligence, the Conference will be an excellent opportunity to gain greater interaction between the communities working in these two fields. Computer technologies and high-performance computing are of key importance for progress in computational medicine and therefore an additional advantage of the Conference will be the inclusion of technical aspects of the use of new computing infrastructures.

The organisationof the Conference is the result of the experience gained by the Sano team during Sano Science Day (2023, 2024) and cooperation in the Life Science Open Space organisation (since 2019) and as well as on a very broad experience of the Faculty of Computer Science AGH and Academic Computer Centre Cyfronet AGH in this area.

Conference topics include

  • Ethical, legal, and social issues in VHT
  • Mathematical medical models
  • Multiscale modelling
  • Computational modelling of organs and diseases
  • Patient data management and processing
  • Methods of acquisition, storage and retrieval of information in medicine
  • Analysis of medical images
  • Machine learning models for healthcare
  • Computer simulations using advanced computing infrastructures
  • Surgical planning tools
  • Model and simulation reproducibility and credibility
  • Clinical decision support systems based on artificial intelligence
  • Towards the Virtual Human Twin platform

Keynote Lectures

Ewa Deelman – University of Southern California, Information Sciences Institute

Opportunities for AI in Modern Cyberinfrastructure: The Case of Scientific Workflow Management

Over the last two decades, scientific workflow management systems (WMSs) have enabled the execution of complex, multi-task applications on a variety of computational platforms, including today’s exascale systems. They ensure efficient execution of computational and data management tasks, adhering to their data and control dependencies. During workflow execution, WMSs monitor the execution of tasks, detect anomalies and failures, and deploy recovery mechanisms when needed. If the workflow cannot be successfully executed, the WMS provides debugging information to help the scientist or cyberinfrastructure (CI) operator fix the problem. However, as workflows and CI grow in scale, heterogeneity, and complexity, traditional WMS approaches face challenges in scalability, adaptability and resilience.

Although research in WMS has explored a number of avenues from workflow composition using semantic technologies to resource provisioning, workflow scheduling, fault-tolerance, and provenance tracking, the methods employed were often heuristics-based and limited in their applicability. With semantic technologies, there was a significant amount of investment in the generation of appropriate ontologies that needed to happen in order to ease workflow composition.  Today, AI technologies are making a significant impact on every aspect of our lives, and they are being used in science as well. Although they are also applicable to CI, potentially making it more performant and resilient, they have not yet made significant inroads.  In this work, we focus on the exploration of the use of AI in the case of workflow management systems, exploring its use throughout the scientific workflow lifecycle from workflow design to workflow execution. We investigate the use of AI in the context of the existing Pegasus WMS, exploring embedding AI in current systems as well as reimaging workflow management to be fully distributed and resilient. This new model is inspired by enhanced swarm intelligence (SI), designed to dynamically adapt to failures and optimize the overall system.

The Pegasus WMS.  Pegasus pioneered the use of planning in WMSs, enabling users to focus on their science by describing their workflows in a resource-independent way. Pegasus takes that description and automatically maps the jobs onto heterogeneous resources, determines the necessary data transfers between jobs, and optimizes the workflow for performance and reliability. The result is an executable workflow that includes compute job submit scripts and data management jobs for the target CI. Pegasus has a notion of the submit host from where the system submits jobs to multiple distributed resources within the CI ecosystem: HTC (high-throughput computing) and high-performance computing (HPC) resources, campus clusters, user-provisioned clouds, and the edge. Pegasus workflows are easy to compose using Python, Java, and R APIs as well as in Jupyter Notebooks, and are portable across heterogeneous CI.

PegasusAI: Integrating AI throughout the workflow lifecycle.  Whereas Pegasus uses simple heuristics, PegasusAI, a new project started in 2025, explores a variety of AI technologies throughout the entire workflow lifecycle.  For workflow composition, we are exploring retrieval-augmented generation, combining the generative capabilities of large language models (LLMs) with retrieval mechanisms, to support workflow discovery and composition by providing context-specific suggestions that users can adapt as needed. Today, the user identifies or provisions the resources needed for execution. Once resources are provisioned, the WMS plans the workflow onto the resources using static heuristics.  PegasusAI will fully automate the resource provisioning and planning steps. The planner will identify the types of resources needed, and then the provisioner will acquire the needed resources before the planner maps the workflow onto them. To make smart decisions, we explore a variety of AI models, including neural network-based models and probabilistic models, to learn about resource and job performance and robustness. Once the workflow is sent for execution, PegasusAI monitors the jobs in real time and performs anomaly and error detection (slow network, overloaded system, application error) using techniques such as Graph Neural Networks, LLMs, or autoencoders that we explored in prior work and decide whether to adapt the execution or the mapping or suggest to the user to modify the workflow. As results are being generated, PegasusAI learns about successful workflow design patterns and their components.

Part of the challenge of adopting AI for CI may be the quick pace of AI development as well as the challenges associated with the deployment of the technologies. Overtime, one needs to have a way of migrating between AI models as the new generations become more capable. This includes the evaluation of new technologies in terms of the validity of the solution, performance, and resource needs, as well as potential additional fine-tuning, “catching up” with the latest model to what the previous version already learned about the CI context. Issues of deployment, such as availability of appropriate computational and storage resources over time to support learning and inferencing, issues of resilience when models are embedded in the CI, or connectivity when queried remotely, need to be taken into account.

SWARM: Scientific Workflow Applications on Resilient Metasystem. Pegasus and PegasusAI are designed to be production-level capabilities. Pegasus is being used today in astronomy, bioinformatics, climate and weather modeling, ecology, earthquake science, gravitational-wave physics,  materials science, chemistry, and AI/ML for science. 

PegasusAI will build on the current capabilities and incrementally incorporate AI to make the system easier to use, more performant, and robust.  However, there are limitations to the current approach, as the system is centralized. SWARM, on the other hand, reimagines the WMS as fully distributed and agentic, making agents responsible for the distributed compute resources across the computing continuum, from the edge to the core.

SWARM integrates swarm intelligence, consensus protocols, and optimized network overlays. Instead of relying on a centralized scheduler, SWARM models job scheduling, data management, and fault recovery as autonomous yet cooperative agents—ranging from lightweight edge agents to LLM-enhanced cognitive agents—that self-monitor, diagnose, and adapt to failures. Consensus plays a central role: heterogeneous agents achieve agreement on job selection and resource allocation using tailored consensus functions and resilient algorithms, such as Practical Byzantine Fault Tolerance and novel greedy variants, which ensure progress even under failures. To address scalability and efficiency, SWARM employs dynamic overlay networks, where the communication topology adapts to resource capabilities and network conditions, balancing local and global connectivity to minimize overhead while maintaining robustness.  The multi-agent work includes a fault-tolerant, fully distributed scheduling architecture that eliminates the single points of failure common in centralized systems. Independent agents manage local resources, monitor system health, and coordinate through competitive bidding, achieving near-optimal job allocation without heavy consensus overhead. SWARN is meant to be a research effort that explores ideas of agentic AI for CI. However, we expect that some of the ideas will be valuable in production.

Acknowledgements: PegasusAI is supported by the U.S. National Science Foundation under grant #2513101. SWARM is funded by U.S. Department of Energy under grant #DE-SC0024387.

Ewa Deelman, University of Southern California

Liesbet Geris – KU Leuven, VPH Institute

Building the Virtual Human Twin: from an engaged ecosystem to an incipient infrastructure

Following the definition of the European Commission, a Virtual -Human Twin (VHT) is a digital representation of a human health or disease state. VHTs refer to different levels of human anatomy (e.g. cells, tissues, organs or organ systems). They are built using software models and data and are designed to mimic and predict behaviour of their physical counterparts, including interaction with additional diseases a person may have. The key potential in health and care of this technology is related to targeted prevention, tailored clinical pathways, and to supporting healthcare professionals in virtual environments. Examples include implementation of clinical trials for medicines and devices, medical training, surgical intervention planning, and several other potential use cases in virtual world environments. A public VHT infrastructure is the subject of an ongoing tender. This infrastructure should enable the pooling of resources and assets (data, models, algorithms, computing power, storage etc.) to develop these twins in healthcare and assess their credibility. Hence, it should entail the development of a federated public infrastructure and the collection of said resources, driven by the engagement of a collaborative ecosystem.

In order to realise the potential of the VHT, a shared vision and inclusive eco-system driven roadmap has been developed, supported through the EDITH Coordination and Support Action. The roadmap contains a blueprint of the Virtual Human Twin and  will identify the required (technical) developments, including but not limited to interoperability,  computability, hardware and integration of health models & data. Ethical, Legal and Social elements are discussed, including privacy, intellectual property rights, standards, regulations, ethics and social acceptance. The user perspective is developed for a range of stakeholders, whose needs and value propositions have been identified through a range of activities and interactions. Finally, sustainability of the ecosystem and infrastructure are examined, looking at incorporation in clinical and industrial workflow, development of economic activities, a member-state strategy and the creation of a public research infrastructure organisation. Recommendations for all involved stakeholders have been formulated. The final draft of the roadmap can be found here: https://zenodo.org/records/14645647.

In this talk I will discuss the current status and challenges that lie ahead on the road to realization of the vision of the Virtual Human Twin, using examples of my own research group as well as the work of colleagues.   

Liesbet Geris

University of Liège, KU Leuven & VPH Institute, Belgium

Tomasz Gosiewski – Jagiellonian University Medical College 

The digestive tract microbiome – where does it come from, how does it change, and what is its connection with the brain?

Microbiome it is a mysterious phenomenon that is talked about and written about in the media. Often mistakenly referred to as flora or microflora, but it has nothing to do with plants. So what is the microbiome? It is a large collection of genes of microorganisms that inhabit their host and usually do not harm it, but on the contrary, cooperate with it. Sometimes another term also appears, namely microbiota. The microbiota is nothing more than all the cells or viruses that inhabit their host. So why two separate terms, the microbiome and the microbiota? Because by using research methods based on genetic analysis, we study the genes of microorganisms, i.e. the microbiome, and by detecting individual cells of microorganisms directly, we describe the microbiota. However, genetic studies provide a more comprehensive understanding of our microscopic neighbours, so they are preferred by scientists.

We acquire the microbiome at birth, because this is when the newborn has “first contact” with microorganisms, although some believe that this happens while still in the womb. What this contact will be like depends on the type of birth, and the optimal one is the natural one. As it passes through the birth canal, the newborn and its digestive tract are colonized by bacteria that inhabit the vagina, which are the beginning of the normal microbiome. If the mother feeds the newborn with her own milk, she additionally supports the developing microbiome. Delivery by caesarean section causes bacteria from the hospital environment (pathogenic, multidrug-resistant) to enter the newborn’s digestive tract first and they initiate the microbiome (abnormal). The microbiome profile in the first days and weeks of life determines the likelihood of developing inflammatory diseases later in life. An abnormal gut microbiome increases the risk of diseases such as diabetes, obesity, inflammatory bowel disease, allergies, autoimmune diseases, autism, and many others.

Is the microbiome related to the brain? It is surprising, but scientific discoveries indicate that it is. The composition of the gut microbiota influences the dense network of neuronal connections that wraps around the gut. Neurons produce neurotransmitters such as serotonin, norepinephrine, dopamine and others. The microbiota influences the chemical profiles of neurotransmitters in the gut, which in turn transported through the blood to the brain and affect it. On the other hand, the brain, through the vagus nerve, influences intestinal peristalsis and, therefore, the microbiota. These interactions are being studied intensively and are an exciting field for neuroscience and neuropsychoatrics.

Tomasz Gosiewski

Head of Microbiome Research Laboratory; Chair of Microbiology; Molecular Medical Microbiology Department

Faculty of Medicine Jagiellonian University Medical College

Alfons Hoekstra – University of Amsterdam

Towards Digital Twins for Cerebral Blood Flow and Perfusion Pathologies

A multiscale computational model for for cerebral blood flow, perfusion, and tissue metabolism will be introduced. The main components are: (1) a 0D blood flow model including the heart, large systemic arteries, the Circle of Willis, and smaller cerebral arteries projecting on the pial surface; (2) a 3D brain perfusion model using a three-compartmental porous medium approach capturing the length scales of the arterial, capillary, and venule vessels of the brain; and (3) a tissue metabolism and tissue death model. Details of the components and their couplings will be discussed, as wel as validation results. Two examples of digital twin using these computational models will be introduced: (1) estimation of infarcts in acute ischemic stroke patients (using the fully coupled model); (2) estimation of orthostatic hypotension in elderly individuals (only relying on the 0D blood flow component). 

Joanna Jaworek-Korjakowska – AGH University

Artificial Intelligence in Orthodontics: From Automated Diagnostics to Personalized Treatment

Artificial intelligence (AI) is increasingly transforming orthodontics by enabling more precise diagnostics, treatment planning, and patient monitoring. Machine learning algorithms applied to radiographs, 3D scans, and intraoral images can automatically detect anatomical landmarks, classify malocclusions, and predict treatment outcomes with high accuracy. Deep learning models facilitate automated cephalometric analysis, reducing human error and saving clinical time. In addition, AI-powered simulation tools allow for individualized treatment planning, such as predicting tooth movement and optimizing aligner design. Beyond diagnostics and planning, AI supports remote monitoring through image-based progress tracking, enhancing patient engagement and enabling timely interventions. Ethical and clinical considerations, including data privacy, bias, and explainability, remain central to integrating AI safely into practice. Overall, AI offers significant potential to improve efficiency, accuracy, and personalization in orthodontic care, paving the way for more accessible and patient-centered treatments.

Emiliano Ricciardi – IMT School for Advanced Studies Lucca, Lucca, Italy

Modeling the Sensory-Deprived Brain: Insights from Neuroimaging, Computational Neuroscience, and Machine Learning

How does the brain adapt to the absence of an entire sensory modality from birth? This question has long fascinated neuroscientists interested in the balance between neural plasticity and biological constraints. In this talk, I will present recent efforts from our group at the IMT School for Advanced Studies Lucca, where we integrate high-resolution neuroimaging and machine learning approaches to explore how the brain reorganizes itself under conditions of congenital sensory deprivation. 

Combining techniques such as multivariate pattern analysis, machine learning approaches and functional network modeling to neuroimaging data, we describe how distributed brain networks reorganize and how conceptual knowledge emerges independently of visual input. We then feed these neural signals into deep generative models, allowing us to reconstruct high-level visual representations from brain activity in congenitally blind individuals.

These interdisciplinary approaches reveal a dual nature of cortical organization: a stable, hierarchically structured architecture that persists without sensory input, and a flexible layer of experience-driven reallocation. By bridging empirical and computational neuroscience, our work contributes to a deeper understanding of how the human brain maintains functional integrity and cognitive richness even in the face of profound sensory absence.

Daniel Taylor – University of Sheffield

Computing coronary physiology: Conception, Optimisation and Clinical application

Computed coronary physiology (virtual FFR) is now established in clinical practice. Our group recently developed a model for predicting absolute flow and hyperaemic coronary microvascular resistance using pressure wire and angiographic data. In this talk I will first outline how we developed the model and implemented side branch flow. I will then cover the optimisation and validation of these advancements. Finally, I will discuss how the model may be used to enhance clinical practice, by applying it retrospectively to data from the landmark ORBITA trial. Specifically, I will explore the relationship between disordered coronary microvasculature and the symptomatic response to percutaneous coronary intervention in patients with stable angina.

 Honorary patronage

The conference is held under the honorary patronage of the Mayor of the City of Kraków, Aleksander Miszalski.

Media patronage

No registration fee, conference by invitations 

Proceedings KCCM 2025

Regulations Krakow Conference on Computational Medicine 2025

Regulations Krakow Conference on Computational Medicine 2025

§ 1

GENERAL INFORMATION

1. Definitions of the terms used in these Regulations:

      a. Abstract – a text (summary) presenting the main assumptions of the submitted scientific presentation that the person interested in the Speaker’s role intends to present during the Event.

      b. Candidate – a student or graduate who has correctly completed the registration form in the Registration System and has submitted an Abstract.

      c. Organizer/Organizers shall mean: 

      i. Sano – Centre for Computational Personalised​ Medicine – International Research Foundation seated in Kraków at 36/C5 Czarnowiejska Streat. 30-054 Krakow, NIP (Tax ID Number): 6772446472, REGON: 384298430, KRS 0000797490, hereinafter referred to as “Sano”.

      ii. the AGH University of Krakow, the Academic Computer Centre Cyfronet AGH, seated in Krakow at 11 Nawojki Street, NIP (Tax ID Number): 675-000-19-23, REGON 000001577-00022, 

      iii. the AGH University of Krakow, the Faculty of Computer Science, seated in Krakow at 21 Kawiory Street, 30-055 Krakow, NIP (Tax ID Number): 675-000-19-23, REGON 000001577-00022.

      d. Regulations – these Regulations of the Event organised by the Organizers, made available on the Event website at https://sano.science/other-events/krakow-conference-on-computational-medicine-2025/ in a manner that makes it possible to download, reproduce, and record the Regulations in English.

      e. Speaker – a person selected by the Program Committee according to Section 3 of the Regulations or a person who has received an invitation from the Organizers to deliver a lecture/speech or lead a Tutorial.

      f. Registration System – an electronic system available at https://events.plgrid.pl/e/kccm2025 designed for submitting abstracts and registering to participate in the Event.

      g. Participant shall mean:

      i. a Candidate who has been selected by the Program Committee and has correctly completed the registration form for participation in the Event in the Registration System, or

      ii. a person who has received an invitation to the Event and has correctly completed the registration form for participation in the Event in the Registration System, or

      iii. a Speaker who has correctly completed the registration form for participation in the Event in the Registration System.

      h. Tutorial – an interactive practical session led by Participants in the Event, aimed at sharing knowledge and developing skills through the active involvement of other participants.

      i. Event – the Krakow Conference on Computational Medicine 2025 – Enhancing Virtual Human Twin with AI Solutions,organized by the Organizers at the Faculty of Computer Science of the AGH University, in Building D17 at 21 Kawiory Street, 30-055 Krakow, on October 15-17, 2025.

      § 2

      GENERAL PROVISIONS AND CONDITIONS FOR PARTICIPATION

      1. The Event Organizers are Sano – Centre for Computational Personalised Medicine – International Research Foundation, the Academic Computer Centre Cyfronet AGH at the AGH University of Krakow, and the Faculty of Computer Science of the AGH University of Krakow.

      2. The provisions of these Regulations apply to Candidates and Participants in the Event.

      3. The Event will be held at the Faculty of Computer Science of the AGH University, in Building D17 at 21 Kawiory Street, 30-055 Krakow, on October 15-17, 2025; however, the Tutorials may be held in other locations to be specified in the Event schedule published at https://events.plgrid.pl/e/kccm2025, particularly at the premises of the Organizers organizing individual Tutorials.

      4. The Event will be conducted in English, in an in-person form. The Organizers do not provide an interpreter.

      5. The Organizers reserve the right to stream the Event (in whole or in part at their discretion), also online via YouTube (hereinafter referred to as the “Website”). In this situation, Participants who are not Speakers will be informed about the option to participate in the Event online via email sent to the email address provided in the form.  The option to participate in the Event online does not apply to the Speakers.

      6. Participants register to participate in the Event by completing the registration form in the Registration System correctly and ticking the appropriate selection button, by which the registrant declares that they have read the Regulations and accept their provisions.

      7. Completing and submitting the form along with ticking the appropriate selection button referred to in Paragraph 6 is tantamount to the Participant’s accepting these Regulations.

      8. The Organizers take no responsibility for the consequences of providing incorrect data when registering for the Event or submitting Abstracts. Participants are required to update their contact details.

      9. When completing the registration form for the Event, Participants select the Tutorials in which they wish to participate. The number of places for individual Tutorials is limited, and applications will be handled on a first-come, first-served basis. If all places for the Tutorial selected by the Participant are filled, the Organizer will inform the Participant about available places and the option of registering for Tutorials with available places.  

      10. A Participant may only a person who:

      a. has the full capacity to perform acts in law, and

      b. has received an invitation from the Organizers to participate in the Event actively or inactively, or is a Candidate selected by the Program Committee, and

      c. has correctly completed the registration form in the Registration System, and

      d. has accepted these Regulations.

      All the conditions indicated above in points a. to d. must be met jointly.  

      11. A maximum of 150 Participants may participate in the Event. The Organizers reserve the right to stop accepting applications for participation early if all the places are filled.

      12. Qualified Participants will be informed about this fact by email to the email address provided in the form. The Organizers reserve the right to use the email address provided during registration for the Event to notify the Participants and confirm their right to participate in the Event. A Participant acquires the right to participate in the Event upon receiving confirmation of qualification for the Event from the Organizers; at that moment, an agreement is concluded between the Organizers and the Participant for participation in the Event on the terms and conditions specified in the Regulations.

      13. In the case of any technical problems, doubts, or other matters relating to the Event, the Candidate/Speaker/Participant should contact the Organizer at kccm@sanoscience.org. An approximate response time is three business days; however, the Organizer reserves the right to respond within a longer period. 

      14. The Organizer reserves the right to refuse to allow a Participant/Candidate to participate in the Event if they have breached the provisions of these Regulations, particularly in the case of submitting false statements in the registration form.

      15. The Event Schedule is available on the Event website and may be subject to changes; such a change does not constitute an amendment to the Regulations. The changed Schedule will be announced on the Event website.

      16. A Participant has the right to forgo participation in the Event in the case of important and unforeseen circumstances until October 8, 2025. The Participant is required to inform the Organizer immediately by sending information to the email address: kccm@sanoscience.org.

        Should a Participant forgo participation, the Organizer will inform the next person in the standby list about the option of participating in the Event. The Participant is required to respond within 3 calendar days from the date of receiving information about the option of participating in the Event.

        17. The Event is free for the Participants.

        18. Each Participant is required to abide by the law and these Regulations.

        § 3

        SUMMITING ABSTRACTS AND REQUIREMENTS FOR SPEAKERS

        1. To submit an Abstract, an interested person should complete the relevant registration form in the Registration System and submit the Abstract following the instructions and guidelines provided in the Registration System.

        2. Abstracts should be presented in line with the requirements and template provided at https://events.plgrid.pl/e/kccm2025, should be original, and should be submitted as a digital text file in .docx format. The Organizers reserve the right to make any necessary corrections to the content of submitted Abstracts following a consultation with the Abstract’s author.

        3. The Program Committee appointed by the Organizers will analyse the Abstracts and select Participant – Speakers. The Organizers reserve the right to select certain Abstracts. Abstracts will be accepted or rejected based on their subject matter and the Event concept by the Program Committee appointed by the Organizers.

        4. The Program Committee will make the decisions referred to in Paragraph 3 above at its discretion, guided by the need to ensure a wide variety of topics of the Event and its high scientific level. The Program Committee’s decision is final and requires no justification; the Participants are not entitled to appeal against the decision.

        5. The deadline for submitting Abstracts is provided on the Event website at https://events.plgrid.pl/e/kccm2025. The Organizers reserve the right to extend the deadline; they will inform Candidates about the deadline extension by announcing it on the Event website.

        6. Based on the submitted Abstracts, the Program Committee will select from among the Candidates those qualified to participate in the Event and will inform the Candidates about the qualification result by email to the address provided when submitting the Abstracts. Further contact to determine the form and details of the Abstract presentation will be maintained in a manner agreed upon by the selected Candidate and the Organizers.

        7. Abstracts selected by the Program Committee will be published in the Krakow Conference on Computational Medicine – Book of Abstracts. The Organizer will decide upon the date, form, and manner of publishing the Krakow Conference on Computational Medicine – Book of Abstracts and making the Abstracts available in this form for dissemination.

        8. Selected Abstracts will be presented during the Event in the form of a paper, along with an accompanying oral or poster presentation. The Program Committee is responsible for approving the Authors’ choices of one of the said forms of presentation.

        9. The Candidates whose Abstracts have been selected according to the rules referred to above are also required to register for the Event, particularly to confirm via the form in the Registration System that they have read and accepted the content of the Regulations.

        10. Submitting an Abstract constitutes simultaneously a declaration by the Abstract’s authors that:

        a. the Abstract is completely original and contains no borrowings from another work that could result in the Organizers’ liability, including as publishers,

        b. the Abstract has never been previously published in its entirety,

        c. the copyright to the Abstract is unlimited within the scope covered by this declaration,

        d. neither the Abstract nor its individual elements will infringe on any third-party rights, and the Abstract’s authors hold the rights to both the text and tables, as well as the illustrative material (photographs, drawings, and charts),

        e. the publisher of Krakow Conference on Computational Medicine – Book of Abstracts has the right to make any necessary changes to the Abstract resulting from editorial work.

        11. Should any of the declarations made as referred to in Paragraph 10 above prove to be untrue, the author will be liable to the Organizers for any resulting damage.

        12. By submitting an Abstract, the Abstract’s author grants each of the Organizers a gratuitous and non-exclusive licence unlimited in terms of time, territory, quantity, and quality to use the Abstract to make a decision on qualifying the Candidate to present the Abstract, organize and conduct the Event, as well as prepare and publish conference materials, including the Krakow Conference on Computational Medicine – Book of Abstracts, which will be published and made available in print and may be shared in electronic form by posting it on the Event website or the Organizers’ websites to be downloaded by an unlimited number of recipients.

        13. The licence referred to above is granted with the right to grant sublicences, with a scope corresponding to the licence, for using the Abstract in whole or in part, individually or in combination with other works, materials, and legally protected elements selected freely by the Organizer. The licence covers the use of the Abstract to the fullest extent permitted by law, including the fields of exploitation referred to in Article 50 of the Copyright and Related Rights Act, particularly in the following fields of exploitation:

        a. recording and reproducing the Abstract by producing copies of the Abstract by any technique, including printing, IT, and photographic techniques, magnetic recording, and digital techniques (including DVDs and magneto-optical media) in an unlimited number of copies, including by publishing in the Krakow Conference on Computational Medicine – Book of Abstracts;

        b. disseminating the Abstract by publishing it in the Krakow Conference on Computational Medicine – Book of Abstracts and its dissemination, public performance, exhibition, presentation, display, broadcasting, and rebroadcasting, as well as making the Abstract available to the public in such a way that everyone can have access to it at a place and time of their choice, using all available techniques, including by using it on the Internet, Intranet, and other computer networks, broadcasting the Abstract via multimedia and ICT networks, particularly on the Event website, the Organizers’ websites, in their social-media profiles and on websites;

        c. trading in the original or copies in which the Abstract has been recorded by marketing, lending, or renting the original or copies;

        d. creating and distributing works derivative from the Abstract, including further projects/materials based on the Abstract or its individual elements, including preparing different graphic or colour versions and visual or spatial formats of the Abstract and using the derivative works thus created within the scope and in all the fields of exploitation specified in this Section;

        e. modifying and elaborating the Abstract in whole or in part, which includes, among other things, the right to correct, modify, and change the entire Abstract or its individual elements, as well as use and distribute elaborations of the Abstract;

        f. recording the Abstract permanently or temporarily and reproducing it in whole or in part by any means and in any form.

        14. The licence referred to in Paragraph 13 above also includes the right for the Organizer and persons acting on its behalf to exercise derivative rights to the Abstract in all the fields of exploitation referred to in Paragraph 13 above, including, in particular, the right to introduce changes to the Abstract and prepare elaborations thereof, to use, distribute, and dispose of derivative works, and the right to allow third parties to exercise derivative copyrights to the Abstract to the extent corresponding to that exercised by the Organizer.

        15. The provisions of Section 6, Sections 2-3 and 5-7 apply to the Abstract accordingly.

        16. If the Abstract is authored by more than one person, the Candidate submitting the Abstract warrants they hold a valid and effective power of attorney from the other co-authors to grant the consents, licences, and permits referred to in this Paragraph, and indicates the Speaker’s details.

        17. The publisher of the Krakow Conference on Computational Medicine – Book of Abstracts is Sano.

        § 4

        EVENT RULES; PARTICIPANTS’ RIGHTS AND OBLIGATIONS

        1. A detailed programme of the Event will be published at https://events.plgrid.pl/e/kccm2025 by September 22, 2025. The Organizers reserve the right to change the programme, Event location, topics, and Speakers. Changes to the programme do not constitute an amendment to the Regulations. Changes will be published on the Event website. The Organizer will not be responsible to the Participants for any compensation or other claims on this account.

        2. Sano is the exclusive owner of all intellectual rights relating to the Event, such as present and future rights to the Event name, logo, marks, and the like. Exercising these rights requires Sano’s prior written consent in order to be valid and must be carried out in line with Sano’s instructions and guidelines.

        3. The Participants bear full financial responsibility for any damage they cause. The Participants bear sole responsibility for violating generally applicable laws and regulations or infringing on the rights of third parties. The Organizers’ liability in this regard is excluded.

        4. To the extent permitted by law, the Organizers take no responsibility for any material or non-material damage suffered by the Participants as a result of participating in the Event. The Organizers are not liable for any damage caused by third parties or the fault of an injured party. The Organizers are not liable for damage caused by force majeure.

        5. The Organizers are not responsible for material things left unattended during the Event.

        6. The Organizers neither cover nor reimburse the costs of participating in the Event or the costs of travel, meals, and accommodation.

        7. The Organizers take no responsibility for the content presented by the Speakers.

        8. The Participants are required to comply with the safety rules, OHS and fire regulations in force on the premises where the Event is organised, and the sanitary regime rules applicable at that time, as well as these Regulations. If a Participant disturbs public order and fails to comply with the applicable sanitary rules or disrupts the course of the Event, undertakes actions that are illegal, contrary to public morals, or harmful to legitimate interests of third parties or that are intended to circumvent or indicate an attempt to circumvent these Regulations or the rules for holding the Event, or undertakes actions that jeopardize the Organizer’s legitimate interests or tarnish its image, the Organizer’s staff is entitled to:

        a. request the Participant to behave appropriately;

        b. request the Participant to leave the premises where the Event is held or exclude the Participant from the Event;

        c. call relevant services in a situation where the behaviour qualifies for such an intervention, in particular, when it poses a threat to other Participants or the Organizer’s staff or property, third parties, or the owner of the facility where the Event is held.

        9. The Organizer takes no responsibility for any events resulting from the Participants’ failure to comply with the Regulations or follow the Organizer’s recommendations, as well as instructions of the Event staff and services responsible for safety and order.

        10. In the event of noticing a threat to the life and health of Participants, the Participant is obliged to inform the Organizer’s staff immediately.

        11. The Organizers may refuse entry to or presence at the Event to persons whose behaviour may pose a threat to other Participants.

        12. The Event may be cancelled or interrupted at any time if its commencement or continuation poses a threat to the Participants’ safety.

        13. When providing Participants with conference materials, in particular, multimedia presentations, posters, and publications, the Event Organizer draws the Participants’ particular attention to the need to respect intellectual property rights. The Participants undertake to use the conference materials provided by the Organizer only for their personal use. Modifying, copying, transmitting, displaying publicly, and using these conference materials for commercial purposes requires prior written consent granted by the Organizer or another authorized entity. The Participants are fully liable for any damage resulting from their behaviour contrary to the foregoing provision.

        14. By taking part in the Event, the Participants accept the rules established for the Event and its programme and undertake not to cause its changes or disrupt the course of the Event.

        § 5

        PERSONAL DATA

        1. The Organizers process jointly personal data of all persons involved in organizing and holding the conference and act as Joint Controllers of personal data based on an agreement in this regard.

        2. Data Subjects have the right to:

        a. require access to data,

         b. rectification of data,

         c. erasure of data,

         d. limitation of the data processing,

         e. object to the data processing;

         f. withdraw their consent to the date processing if the processing is based on their consent.

        3. Detailed information on the personal data processing can be found at https://events.plgrid.pl/e/kccm2025, in the “Privacy Policy” tab.

        § 6

        SPEAKER

        1. Speakers are required to register their participation in the Event as referred to in Section 2 for Participants. 

        2. Speakers are fully responsible for the form and content of their lecture/speech/poster.

        3. If any part of a lecture/speech/poster constitutes legally protected elements to which the Speaker holds no right, the Speaker warrants that they are entitled to use them to the extent necessary to deliver the lecture/speech or display the poster, and grant the Organizer a licence with the right to grant sublicenses referred to in this Paragraph without the need for the Organizer to obtain additional consents and permissions. Upon presentation of the lecture, the Speaker grants the Organizer further licences, permissions, and authorizations to use the legally protected elements referred to in this Paragraph to the extent indicated therein.

        a. By starting to deliver the lecture/speech or exhibiting the poster, the Speaker accepts that they will be recorded by the Organizers or an entity acting on their behalf in the form of an audio-video recording or a photograph.

        4. The Speaker grants the Organizers a free and non-exclusive licence unlimited in terms of time, territory, quantity, and quality, with the right to grant sublicences with a scope corresponding to this licence, for:

        – recording in any form, including audio-video recording and a photo report, the lecture/multimedia presentation accompanying the lecture delivered by the Speaker or the poster and using them within the scope and in the fields of exploitation corresponding to those referred to in Section 3, Paragraphs 13 and 14, with the right to grant sublicences with a scope corresponding to this licence.

        – using the lecture/presentation/poster recorded as an audiovisual recording or in a photographic form, in whole or in part, alone or as part of a collective work, in combination with works and elements freely selected by the Organizer(s) (including lectures by other Speakers, the graphic design of the platforms on which it would be placed, images, and sounds), as well as its elaborations, adaptations and all materials, graphics, fragments, shots, and documentation created both during and after the recording, for informational, documentary, educational, didactic, advertising, and promotional purposes of the Organizer and the Event, including, in particular, using and sharing on the Internet and as part of telecommunications services, using any systems and devices, on the Organizers’ social-media sites and other websites, and on the Event website, particularly in social medias such as Facebook, YouTube, LinkedIn, X, Instagram, Slack, and the like.

        5. Should a third party file any claims against the Organizer or entities authorized thereby to use the lecture/poster/Abstract for using these works or their individual elements, the Speaker will indemnify the Organizer and the persons authorized thereby to use the same and will hold them harmless from and against the claims in question to the extent that the Speaker has been obliged to acquire the rights to legally protected elements from the third party, including copyrights and related rights to these works and their individual elements, the right to exercise dependent rights, as well as permits and authorizations referred to in these Regulations, and will be fully liable for any damage incurred by the Organizer and the persons authorized thereby to use the lecture/poster/Abstract on account of the claims referred to above filed against them.

        6. The Speaker undertakes towards the Organizers not to exercise any moral rights.

        § 7

        IMAGE

        1. The Organizer will record the course of the Event using sound and image recording devices in the form of photographs, photo reports, and recordings, respectively, for educational, teaching, informational, documentary, advertising, and promotional purposes of the Organizer and the Event.

        2. By registering for the Event, the Participant grants their consent unlimited in terms of time, territory, quantity, and quality to the use of their voice and image (including their statements or fragments thereof) for the purposes indicated in Paragraph 1 above, without the right to any remuneration for the foregoing, in particular, through recording the Participant’s voice and image in a photo report and/or recording and using this recording, processing (modifying, cropping, or using to create compositions), reproducing, and disseminating repeatedly the Participant’s voice and image recorded in the said manner, including, among other things, in photos and video materials (including advertisements and self-promoting materials), poster designs, leaflets, portfolios, and other promotional, marketing, and/or information materials, without the need for their individual approval to the extent and in a manner corresponding to that referred to in Section 6, Paragraph 5 of these Regulations, including, in particular via the Internet on the Organizer’s website, in the Organizer’s social medias, on the Organizer’s website and other websites and on the Event website, particularly in social medias such as Facebook, YouTube, Instagram, LinkedIn, X, Slack, and the like.

        3. The Participant is aware that the photo report and recording of the Event will be shared on the Internet and will be available on the Organizer’s website, social-media profiles, and platforms such as YouTube, Facebook, Instagram, LinkedIn, X, Slack, and the like to an unlimited number of people without a time limit.

          § 8

          CONFIDENTIALITY

          1. Any and all content of correspondence with the Organizers is considered confidential. It is forbidden to publish such materials or transfer them to third parties in any form without the Organizers’ prior written consent (reserved for such publication or transfer to be valid).

          2. All materials made available to Participants during the Event also constitute confidential information and may only be accessed by the Participants in the Event and its Organizers, unless the presenters indicate during the Event that the information may be further disseminated.

          3. Violating Paragraphs 1 or 2 above will also be treated as disclosing confidential information and will be subject to relevant sanctions pursuant to Polish laws and regulations.

          § 9

          PROVIDING SERVICES BY ELECTRONIC MEANS

          1. In the situation referred to in Section 2 Paragraph 5 hereof, these Regulations constitute the regulations for providing services by electronic means referred to in Article 8 of the Act of 18 July 2020 on Providing Services by Electronic Means (consolidated text: Journal of Laws of 2020, item 344, as amended). The service provided by the Organizers will be a gratuitous service allowing Participants to participate in the Event on the terms specified in the Regulations to the extent referred to in Section 2 Paragraph 5 hereof, i.e. providing access to the transmission of the Event.

          2. In the situation referred to in Section 2 Paragraph 5 hereof, completing the registration form in the Registration System correctly and ticking the appropriate selection button, by which the registrant declares that they have read the Regulations and accept their provisions, as well as receiving confirmation of qualification to participate in the Event from the Organizers, is tantamount to concluding an agreement with the Organizers for participation in the Event.

          3. The Participant may terminate the agreement on the terms referred to in Section 2 Paragraph 16 and opt out of the service provided electronically at any time by leaving the Website.

          4. Participants are required to attend the Event and use the Website in compliance with applicable laws and regulations, the principles of social conduct, these Regulations, the terms of use of the Website, and accepted customs, particularly without violating the rights of other Participants in the Event.

          5. For the proper use of the services referred to in this Section, the following is required:

          a. a device with Internet access,

          b. an up-to-date web browser (such as Chrome, Firefox, or Safari),

          c. an active email account,

          d. access to YouTube (without the need for an account used via a link in a web browser).

          6. The Participant is required not to send or publish illegal content violating third-party rights or public morals.

          7. The Participants use the transmission for their own benefit. It is forbidden to:

          a. record, copy, or distribute the content of the Event,

          b. share the link to the transmission with unauthorized persons without the Organizer’s consent

          8. The Organizer is not responsible for any technical problems on the Participants’ side that may affect their ability to participate in the Event, particularly those related to the Internet connection.

          9. The Organizer is not responsible for any disruptions, including interruptions, in the operation of the Website caused by force majeure, unauthorized actions of third parties, or incompatibility of the Website with the Participant’s IT infrastructure.

          10. To the extent permitted by applicable laws and regulations, particularly Article 473(2) of the Civil Code, the Organizer disclaims all liability for any consequences related to the Participants’ attendance in the Event, including damage resulting therefrom or their inability to attend it, in particular, damage resulting from faults/failures/defects of the Website resulting from reasons beyond the Organizer’s control.

          11. Participants may file complaints regarding the Event in writing at the Organizer’s office or to the following email address: kccm@sanoscience.org

          12. When submitting a complaint, the Participant is required to provide (i) their first name and surname, (ii) their correspondence address, (iii) the reason for submitting the complaint, (iv) the date of the circumstances referred to in the complaint, and (v) the date of submitting the complaint.

          13. The Participant has the right to submit a complaint within not more than 14 days from the end of the Event.

          14. At the Organizers’ request, the Participant is required to provide additional information or supplement the information indicated in Paragraph 12 above, necessary to examine the complaint. If the Organizer determines the need to obtain additional information or supplement the information as indicated in Paragraph 2 above, the Participant is required to send a response in the manner indicated in Paragraph 12 above within 3 days of receiving the information from the Organizer.

          15. The Organizer will examine the complaint within 14 days from the date of its submission by the Participant. A response to the complaint will be sent to the Participant in writing to the correspondence address provided in the complaint or electronically by email (if provided).

          16. Complaints submitted after the deadline referred to in Paragraph 13 above or not containing the data referred to in Paragraph 12 above, or not supplemented within the deadline referred to in Paragraph 14 above, will not be considered. 

          § 10

          FINAL PROVISIONS

          1. Sano declares that the services provided by Sano as a co-organizer are financed from the budget of the Teaming for Excellence project implemented by the Organizer as part of the promotion of the European Union Horizon 2020 research and innovation program under grant agreement No. 85733.

          2. The Regulations are effective as of the date of their announcement on the Event website.

          3. The Organizers reserve the right to amend the Regulations and the Event programme. The Participants will be immediately informed about any amendments to the Regulations by email once the amendments have been introduced.

          4. Amendments to the Regulations come into effect upon publication of the amended Regulations on the Event website.

          5. The Organizers reserve the right to cancel or postpone the Event in the case of circumstances unforeseeable on the date of publication of the Regulations.

          6. Should the Event be cancelled or postponed, the Organizers take no responsibility for any damage suffered by persons who registered for participation in the Event.

          7. By registering for and taking part in the Event, the Participant undertakes to comply with the Regulations.

          8. The Regulations do not limit or exclude the Participants’ rights arising from mandatory provisions of law in any way.

          9. To matters not governed by these Regulations, provisions of Polish law apply, including the provisions of the Civil Code.

          10. The provisions of these Regulations are interpreted in accordance with Polish law. The court competent to resolve any disputes that may arise from the application of these Regulations is the common court with jurisdiction over the Organizer’s registered office.