New paper “Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex”

Authors: Karolina Tlałka , Harry Saxton, Ian Halliday, Xu Xu, Andrew Narracott, Daniel Taylor, Maciej Malawski

We’re excited to announce that Karolina Tlałka and Maciej Malawski from Sano, together with Harry Saxton, Ian Halliday, Xu Xu, Andrew Narracott, and Daniel Taylor, have published a groundbreaking article: “Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex.”

The study explores the critical role of the baroreflex in cardiovascular regulation using innovative closed-loop in silico models. Through global sensitivity analysis, the team uncovered key insights into how parasympathetic arc parameters influence physiological resting states and clinical metrics.

This work represents a significant step toward understanding regulation mechanisms for personalized healthcare applications.

Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex

Authors: Karolina Tlałka , Harry Saxton, Ian Halliday, Xu Xu, Andrew Narracott, Daniel Taylor, Maciej Malawski

DOI: 10.1371/journal.pcbi.1012377

Keywords: baroreflex, sensitivity analysis, cardiovascular system